Prometon

Prometon

SCHEMBL9270641

COc1nc(NC(C)C)nc(NC(C)C)n1.CSc1nc(NC(C)C)nc(NC(C)C)n1

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.53
TSHR P16473 1/20 0.53
HSD17B10 Q99714 1/20 0.53
KMT2A Q03164 4/20 0.49
MEN1 O00255 2/20 0.49
CYP1A2 P05177 1/20 0.49
MAPK1 P28482 3/20 0.47
GAA P10253 3/20 0.42
TDP1 Q9NUW8 2/20 0.42
KCNH3 Q9ULD8 3/20 0.41
TP53 P04637 1/20 0.41
CYP2C9 P11712 1/20 0.40
HTT P42858 3/20 0.39
LMNA P02545 2/20 0.39
F2 P00734 1/20 0.39
MAPT P10636 1/20 0.38
ALDH1A1 P00352 2/20 0.38
KDM4E B2RXH2 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Prometon SCHEMBL9738925 1.00 SMN1; SMN2 (0.53) SMN1; SMN2TSHRHSD17B10KMT2AMEN1
Prometon SCHEMBL7003877 0.92 GAA (0.58) SMN1; SMN2TSHRHSD17B10KMT2AMEN1
Prometon SCHEMBL22999 0.87 KMT2A (0.61) SMN1; SMN2KMT2AMEN1CYP1A2MAPK1
Prometryn SCHEMBL7657627 0.87 MAPK1 (0.56) SMN1; SMN2TSHRHSD17B10KMT2AMEN1
Prometon SCHEMBL1517242 0.87 KMT2A (0.61) SMN1; SMN2KMT2AMEN1CYP1A2MAPK1
Prometryn SCHEMBL7622 0.87 MAPK1 (0.56) SMN1; SMN2TSHRHSD17B10KMT2AMEN1
Prometryn SCHEMBL20723889 0.85 GAA (0.58) SMN1; SMN2TSHRHSD17B10KMT2AMEN1
Ametryne SCHEMBL7006285 0.84 HTT (0.48) SMN1; SMN2TSHRHSD17B10KMT2AMEN1
SCHEMBL11746313 0.82 SMN1; SMN2 (0.50) SMN1; SMN2TSHRHSD17B10KMT2AMEN1
SCHEMBL2682570 0.79 KMT2A (0.53) SMN1; SMN2KMT2AMEN1CYP1A2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1046280-C Novel thiophenesulfonylurea derivative and herbicidal composition containing the same KOREA RES INST CHEM TECH (KR) 1999-11-10 CN disclosed
CN-1134701-A Novel thiophenesulfonylurea derivatives and herbicidal compositions containing the same KOREA RES INST CHEM TECH (KR) 1996-10-30 CN disclosed
WO-1995013276-A1 NOVEL THIOPHENESULFONYLUREA DERIVATIVES AND HERBICIDAL COMPOSITION CONTAINING THE SAME KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1995-05-18 WO disclosed