Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 12/20 | 0.65 |
| ▸ | RXRB | P28702 | 5/20 | 0.65 |
| ▸ | RXRG | P48443 | 4/20 | 0.65 |
| ▸ | RARB | P10826 | 13/20 | 0.53 |
| ▸ | RARG | P13631 | 13/20 | 0.53 |
| ▸ | RARA | P10276 | 11/20 | 0.53 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9269625 | 0.90 | RXRA (0.65) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9184440 | 0.85 | RARB (0.54) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL7698960 | 0.85 | RARB (0.57) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9271780 | 0.83 | RXRA (0.66) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL10410310 | 0.80 | RARA (0.48) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9176637 | 0.80 | RARB (0.64) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL9265392 | 0.80 | RXRA (0.69) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL7720657 | 0.79 | RXRA (1.00) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9187338 | 0.78 | RARB (0.49) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8698451 | 0.78 | RARA (0.80) | RARBRARGRARACYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0405028-B1 | Thiochroman esters of phenols and terephthalates having retinoid-like activity | ALLERGAN INC (US) | 1995-10-11 | — | — | EP | claimed |