SCHEMBL9274244

SCHEMBL9274244

CC(C)c1cccc(C(C)C)c1NC(=O)N(Cc1ccccc1Cl)C1CCC(C2CCCCC2)CC1

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 1/20 0.52
UBE2M P61081 3/20 0.49
DCUN1D1 Q96GG9 3/20 0.49
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
SLC6A2 P23975 4/20 0.44
SLC6A4 P31645 4/20 0.44
POLB P06746 1/20 0.41
NMBR P28336 1/20 0.40
GRPR P30550 1/20 0.40
TP53 P04637 1/20 0.40
SLC6A3 Q01959 3/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
KCNH2 Q12809 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9274246 1.00 GHSR (0.52) GHSRUBE2MDCUN1D1MEN1KMT2A
SCHEMBL9268580 0.90 UBE2M (0.45) GHSRUBE2MDCUN1D1SLC6A2SLC6A4
SCHEMBL9268575 0.90 UBE2M (0.45) GHSRUBE2MDCUN1D1SLC6A2SLC6A4
SCHEMBL9267348 0.86 GHSR (0.52) GHSRUBE2MDCUN1D1MEN1KMT2A
SCHEMBL9267349 0.86 GHSR (0.52) GHSRUBE2MDCUN1D1MEN1KMT2A
SCHEMBL9273510 0.86 UBE2M (0.65) UBE2MDCUN1D1
SCHEMBL9273683 0.86 UBE2M (0.65) UBE2MDCUN1D1
SCHEMBL9273516 0.86 UBE2M (0.65) UBE2MDCUN1D1
SCHEMBL9265655 0.85 UBE2M (0.55) UBE2MDCUN1D1SMN1; SMN2
SCHEMBL9265652 0.85 UBE2M (0.55) UBE2MDCUN1D1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5420164-A Enzyme inhibitors YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1995-05-30 US disclosed
EP-0507291-A1 Cyclohexylurea compounds YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1992-10-07 EP disclosed