SCHEMBL9276237

SCHEMBL9276237

CNc1c(O)cc(Br)cc1C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 3/20 0.48
AKR1C2 P52895 3/20 0.48
AKR1C1 Q04828 3/20 0.48
AKR1C4 P17516 2/20 0.48
HSD17B10 Q99714 1/20 0.43
KDM4E B2RXH2 1/20 0.39
GLA P06280 1/20 0.39
CA12 O43570 2/20 0.38
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
CA7 P43166 2/20 0.38
CA9 Q16790 2/20 0.38
CA14 Q9ULX7 2/20 0.38
ALOX5 P09917 1/20 0.38
PTGS2 P35354 1/20 0.38
ALDH1A1 P00352 1/20 0.38
TSHR P16473 1/20 0.38
CES2 O00748 1/20 0.37
GALR3 O60755 1/20 0.37
CYP1A2 P05177 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL950710 0.83 AKR1C3 (0.55) AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10
SCHEMBL762107 0.81 AKR1C3 (0.44) AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10
SCHEMBL3294953 0.78 AKR1C3 (0.42) AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10
SCHEMBL10345208 0.75 KLKB1 (0.44) KDM4ECA12CA1CA2CA7
SCHEMBL3361120 0.75 AKR1C3 (0.53) AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10
SCHEMBL31068478 0.74 AKR1C3 (0.69) AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10
SCHEMBL8285504 0.74 AKR1C3 (0.69) AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10
SCHEMBL9279442 0.73 PTPN1 (0.43) AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10
SCHEMBL25340705 0.71 AKR1C3 (0.53) AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10
SCHEMBL2965583 0.71 AKR1C3 (0.53) AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0643686-A1 NEW COMPOUNDS Astra Aktiebolag (SE) 1995-03-22 EP disclosed
WO-1993005012-A1 NEW COMPOUNDS AB ASTRA (SE) 1993-03-18 WO disclosed
EP-0530166-A2 3-Hydroxy anthranilic acid derivatives for inhibiting 3-hydroxy anthranilate oxygenase Astra Aktiebolag (SE) 1993-03-03 EP disclosed