Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.41 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL950710 | 0.83 | AKR1C3 (0.55) | AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10 | |
| SCHEMBL9276237 | 0.81 | AKR1C3 (0.48) | AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10 | |
| SCHEMBL5094596 | 0.81 | METAP2 (0.57) | ALDH1A1HMGB1CXCL12METAP2KDM4E | |
| SCHEMBL22636387 | 0.78 | ALDH1A1 (0.56) | AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10 | |
| SCHEMBL4314430 | 0.78 | ALDH1A1 (0.44) | AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10 | |
| SCHEMBL29021130 | 0.77 | HTR1D (0.41) | MAPTALDH1A1KDM4ETAS1R3TAS1R1 | |
| SCHEMBL29606250 | 0.77 | HPGD (0.44) | MAPTALDH1A1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL11972812 | 0.77 | AKR1C3 (0.47) | AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10 | |
| SCHEMBL24399523 | 0.76 | AKR1C3 (0.50) | AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10 | |
| SCHEMBL1071109 | 0.76 | AKR1C3 (0.50) | AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103755681-B | 3-(2,2,3,3-tetrafluoropropoxy)-pyrazole amide compound and application thereof | UNIV QINGDAO SCIENCE & TECHNOLOGY | 2015-04-22 | — | — | CN | disclosed |
| CN-103755681-A | 3-(2,2,3,3-tetrafluoropropoxy)-pyrazole amide compound and application thereof | UNIV QINGDAO SCIENCE & TECHNOLOGY | 2014-04-30 | — | — | CN | disclosed |
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| CN-101437519-A | Indazole compounds | ABBOTT LAB (US) | 2009-05-20 | — | — | CN | disclosed |
| EP-2001480-A2 | INDAZOLE COMPOUNDS | Abbott Laboratories (US) | 2008-12-17 | — | — | EP | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
| WO-2007117465-A2 | INDAZOLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282101-A1 | Indazole compounds | CYP3A43, CYP3A7, UGT1A1 | AKR1C3 482/4885AKR1C2 603/4885AKR1C1 488/4885 |
| US-20120053345-A1 | Indazole Compounds | CYP3A43, CYP3A7, UGT1A1 | AKR1C3 482/4885AKR1C2 603/4885AKR1C1 488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.