Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.63 |
| ▸ | PDE4A | P27815 | 8/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6858835 | 0.89 | PDE4D (0.63) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL6858838 | 0.88 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1030283 | 0.82 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL6858726 | 0.82 | PDE4D (0.60) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7340773 | 0.79 | PDE4D (0.76) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1031648 | 0.78 | PDE4D (0.80) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL1026961 | 0.78 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7356316 | 0.78 | PDE4D (0.60) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL70307 | 0.77 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8554187 | 0.77 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0652868-A1 | INHIBITORS OF c-AMP PHOSPHODIESTERASE AND TNF | RHONE-POULENC RORER LIMITED (GB) | 1995-05-17 | — | — | EP | disclosed |
| WO-1994002465-A1 | INHIBITORS OF c-AMP PHOSPHODIESTERASE AND TNF | RHONE-POULENC RORER LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |