Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.43 |
| ▸ | CES1 | P23141 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31362637 | 0.82 | KDM4E (0.50) | LMNATSHRHIF1AHSD17B10CYP1A2 | |
| SCHEMBL10575681 | 0.79 | TSHR (0.46) | LMNATSHRF2CES2CES1 | |
| SCHEMBL4647393 | 0.79 | LMNA (0.50) | LMNATSHRF2CES2CES1 | |
| SCHEMBL28558049 | 0.79 | ELANE (0.45) | TDP1KMT2ARAB9AALDH1A1HSD17B10 | |
| SCHEMBL20174128 | 0.79 | ELANE (0.45) | TDP1KMT2ARAB9AALDH1A1HSD17B10 | |
| SCHEMBL11639951 | 0.78 | NFE2L2 (0.55) | CES2CES1TDP1KMT2AMAPK1 | |
| SCHEMBL11639953 | 0.78 | NFE2L2 (0.55) | CES2CES1TDP1KMT2AMAPK1 | |
| SCHEMBL4645735 | 0.76 | LMNA (0.51) | LMNATSHRF2CES2CES1 | |
| SCHEMBL4645327 | 0.76 | TSHR (0.54) | LMNATSHRF2CES2CES1 | |
| SCHEMBL18838919 | 0.75 | LMNA (0.56) | LMNATSHRF2CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5470975-A | Dihydropyrimidine derivatives | E.R. SQUIBB & SONS, INC. (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0481448-A1 | Dihydropyrimidine derivatives | E.R. SQUIBB & SONS, INC. (US) | 1992-04-22 | — | — | EP | disclosed |