Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.38 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29262985 | 0.86 | HCAR2 (0.43) | HCAR2SMPD1PLA2G4ALMNAGPR35 | |
| SCHEMBL9111559 | 0.85 | SMPD1 (0.40) | SMPD1LMNAGAAMMECHRNA4 | |
| SCHEMBL9113224 | 0.82 | HCAR2 (0.40) | HCAR2SMPD1PLA2G4ALMNAGPR35 | |
| SCHEMBL2722839 | 0.74 | HCAR2 (0.52) | HCAR2SMPD1PLA2G4ATDP1GAA | |
| SCHEMBL4134852 | 0.74 | HCAR2 (0.47) | HCAR2SMPD1PLA2G4AGAAL3MBTL1 | |
| SCHEMBL23930613 | 0.74 | HCAR2 (0.47) | HCAR2SMPD1PLA2G4APTPN1GAA | |
| SCHEMBL26152210 | 0.74 | L3MBTL1 (0.49) | HCAR2SMPD1PLA2G4ALMNAGAA | |
| SCHEMBL9113459 | 0.73 | MTNR1A (0.50) | HCAR2SMPD1 | |
| SCHEMBL26156029 | 0.73 | HCAR2 (0.46) | HCAR2SMPD1PLA2G4APTPN1GAA | |
| SCHEMBL5888245 | 0.72 | SMPD1 (0.57) | HCAR2SMPD1PLA2G4ALMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649062-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF ACETYL-COA CARBOXYLASE (ACC) | Takeda Pharmaceutical Company Limited (JP) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012074126-A9 | BICYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-06-06 | — | — | WO | disclosed |
| WO-2012074126-A1 | BICYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-06-07 | — | — | WO | disclosed |