Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.76 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9166662 | 0.86 | SIGMAR1 (1.00) | SIGMAR1ABCB1 | |
| SCHEMBL9163662 | 0.83 | SIGMAR1 (0.77) | SIGMAR1ABCB1 | |
| SCHEMBL9281388 | 0.78 | SIGMAR1 (1.00) | SIGMAR1DRD2ABCB1 | |
| SCHEMBL9281346 | 0.78 | SIGMAR1 (0.85) | SIGMAR1ABCB1 | |
| SCHEMBL9284248 | 0.77 | SIGMAR1 (1.00) | SIGMAR1ABCB1HTR1A | |
| SCHEMBL9165576 | 0.76 | SIGMAR1 (1.00) | SIGMAR1DRD2ABCB1 | |
| SCHEMBL9247808 | 0.75 | SIGMAR1 (1.00) | SIGMAR1DRD2ABCB1 | |
| SCHEMBL11465528 | 0.74 | SIGMAR1 (0.76) | SIGMAR1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL20512952 | 0.74 | DRD2 (1.00) | DRD2 | |
| SCHEMBL30179315 | 0.74 | DRD2 (1.00) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647222-A1 | N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-04-12 | — | — | EP | disclosed |
| WO-1994000441-A1 | N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY | FARMITALIA CARLO ERBA S.R.L. (IT) | 1994-01-06 | — | — | WO | disclosed |