SCHEMBL9284584

SCHEMBL9284584

CCCCCCc1cc2c(cc1C#Cc1ccccc1CC(=O)OCC)C(C)(C)CC(C)(C)S2

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 2/20 0.35
CYP4A11 Q02928 2/20 0.35
PPARA Q07869 3/20 0.34
PPARG P37231 1/20 0.34
NR4A1 P22736 1/20 0.34
AKT1 P31749 1/20 0.33
IRS1 P35568 1/20 0.33
GAB1 Q13480 1/20 0.33
RARA P10276 1/20 0.32
RARB P10826 1/20 0.32
RARG P13631 1/20 0.32
KDM4E B2RXH2 1/20 0.32
LMNA P02545 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
MAPT P10636 1/20 0.32
CYP2C9 P11712 1/20 0.32
APEX1 P27695 1/20 0.32
CYP2C19 P33261 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9284407 0.91 RARA (0.35) CYP4F2CYP4A11RARARARBRARG
SCHEMBL8865032 0.86 AKT1 (0.31) PPARAPPARGNR4A1AKT1IRS1
SCHEMBL8865556 0.85 PPARG (0.32) PPARAPPARGNR4A1AKT1IRS1
SCHEMBL8865026 0.85 RARA (0.34) AKT1IRS1GAB1RARARARB
SCHEMBL8865725 0.84 KMT2A (0.35) PPARAPPARGNR4A1AKT1IRS1
SCHEMBL8865035 0.83 CYP3A4 (0.34) RARARARBRARGCYP3A4KMT2A
SCHEMBL9180571 0.82 RARB (0.42) RARARARBRARGKDM4ECYP3A4
SCHEMBL8865646 0.81 CYP4F2 (0.34) CYP4F2CYP4A11RARARARBRARG
SCHEMBL8865635 0.81 CYP4F2 (0.34) CYP4F2CYP4A11PPARAPPARG
SCHEMBL8865324 0.80 CYP4F2 (0.33) CYP4F2CYP4A11RARARARBRARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0341158-B1 VITAMIN D DERIVATIVES : THEIR UTILIZATION IN THERAPY AND FOR THE QUANTITATIVE DETERMINATION OF VITAMIN D METABOLITES MEDGENIX DIAGNOSTICS (BE) 1993-01-07 EP claimed
EP-0419131-B1 Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity ALLERGAN INC (US) 1995-07-05 EP disclosed
US-5278318-A Acetylation under Friedel Crafts condition ALLERGAN, INC. (US) 1994-01-11 US disclosed
EP-0553156-A4 CHROMANS AND THIOCHROMANS WITH RETINOID-LIKE ACTIVITY 1993-11-18 EP disclosed
EP-0553156-A1 CHROMANS AND THIOCHROMANS WITH RETINOID-LIKE ACTIVITY ALLERGAN, INC. (US) 1993-08-04 EP disclosed
US-5162546-A ACETYLENES DISUBSTITUTED WITH A PHENYL GROUP AND A 2-SUBSTITUTED CHROMANYL, THIOCHROMANYL OR 1,2,3,4-TETRAHYDROQUINOLINYL GROUP HAVING RETINOID-LIKE ACTIVITY ALLERGAN, INC. (US) 1992-11-10 US disclosed
US-4980369-A ANTIARTHRITIC AGENTS, SKIN DISORDERS, ANTIULCER AGENTS, WOUND HEALING AGENTS ALLERGAN, INC. (US) 1990-12-25 US disclosed