Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5724467 | 1.00 | LMNA (0.51) | LMNAPOLBSMN1; SMN2GBA2GAA | |
| SCHEMBL29812927 | 0.91 | SMN1; SMN2 (0.49) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL4599962 | 0.91 | SMN1; SMN2 (0.49) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL725320 | 0.91 | LMNA (0.58) | LMNAPOLBSMN1; SMN2GBA2GAA | |
| SCHEMBL29813031 | 0.90 | SMN1; SMN2 (0.48) | LMNAPOLBSMN1; SMN2GBA2HPGD | |
| SCHEMBL30380124 | 0.88 | LMNA (0.49) | LMNAPOLBSMN1; SMN2GBA2GAA | |
| SCHEMBL4968757 | 0.87 | LMNA (0.53) | LMNAPOLBSMN1; SMN2GBA2HPGD | |
| SCHEMBL9665931 | 0.87 | SMN1; SMN2 (0.50) | LMNAPOLBSMN1; SMN2GBA2GAA | |
| SCHEMBL6119560 | 0.87 | SMN1; SMN2 (0.50) | LMNAPOLBSMN1; SMN2GBA2GAA | |
| SCHEMBL10610075 | 0.86 | GBA2 (0.49) | LMNAPOLBSMN1; SMN2GBA2P2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760826-A1 | CRYSTALLINE FORMS OF A 3-[2-METHANESULFONYL-1-(4-TRIFLUOROMETHYL-PHENOXY)ETHYL]PYRROLIDINE COMPOUND | Theravance, Inc. (US) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013049617-A1 | CRYSTALLINE FORMS OF A 3-[2-METHANESULFONYL-1-(4-TRIFLUOROMETHYL-PHENOXY)ETHYL]PYRROLIDINE COMPOUND | THERAVANCE, INC. (US) | 2013-04-04 | — | — | WO | disclosed |
| WO-2012075239-A1 | SEROTONIN REUPTAKE INHIBITORS | THERAVANCE, INC. (US) | 2012-06-07 | — | — | WO | disclosed |