Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | GRM3 | Q14832 | 3/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29812927 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2POLBLMNANPC1RAB9A | |
| SCHEMBL29813031 | 0.96 | SMN1; SMN2 (0.48) | SMN1; SMN2POLBLMNANPC1RAB9A | |
| SCHEMBL10609883 | 0.94 | GBA2 (0.49) | SMN1; SMN2POLBLMNANPC1RAB9A | |
| SCHEMBL10610075 | 0.94 | GBA2 (0.49) | SMN1; SMN2POLBLMNANPC1RAB9A | |
| SCHEMBL9285131 | 0.91 | LMNA (0.51) | SMN1; SMN2POLBLMNANR1H4GBA2 | |
| SCHEMBL5724467 | 0.91 | LMNA (0.51) | SMN1; SMN2POLBLMNANR1H4GBA2 | |
| SCHEMBL8324568 | 0.90 | POLB (0.50) | SMN1; SMN2POLBLMNANR1H4GBA2 | |
| SCHEMBL30678922 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBLMNANPC1RAB9A | |
| SCHEMBL8800263 | 0.88 | POLB (0.46) | SMN1; SMN2POLBLMNANPC1NR1H4 | |
| SCHEMBL8800068 | 0.88 | POLB (0.46) | SMN1; SMN2POLBLMNANPC1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903618-B1 | RHO KINASE INHIBITORS | KADMON CORP LLC (US) | 2022-06-01 | — | — | EP | disclosed |
| CN-104703988-A | Novel triazolopyrazine derivative and use thereof | KOREA RES INST CHEM TECH | 2015-06-10 | — | — | CN | disclosed |
| EP-1912967-A1 | QUINOLINE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007012900-A1 | QUINOLINE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2007-02-01 | — | — | WO | disclosed |
| EP-1644334-A1 | ANTITHROMBOTIC ETHERS | Eli Lilly and Company (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2004108677-A1 | ANTITHROMBOTIC ETHERS | ELI LILLY AND COMPANY (US) | 2004-12-16 | — | — | WO | disclosed |