Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.34 |
| ▸ | JAK2 | O60674 | 5/20 | 0.34 |
| ▸ | PAK4 | O96013 | 5/20 | 0.34 |
| ▸ | RET | P07949 | 5/20 | 0.34 |
| ▸ | LTK | P29376 | 5/20 | 0.34 |
| ▸ | KDR | P35968 | 5/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.34 |
| ▸ | JAK3 | P52333 | 5/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.34 |
| ▸ | MST1R | Q04912 | 5/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8907430 | 0.74 | AXL (0.34) | AURKAJAK2PAK4RETLTK | |
| SCHEMBL16743055 | 0.73 | TYRO3 (0.40) | AURKAJAK2PAK4RETLTK | |
| SCHEMBL9280468 | 0.72 | HRH4 (0.34) | LRRK2ADORA2AADORA1 | |
| SCHEMBL15720119 | 0.69 | KCNH3 (0.41) | AURKAJAK2PAK4RETLTK | |
| SCHEMBL15557725 | 0.68 | PRKCI (0.39) | AURKAJAK2PAK4RETLTK | |
| SCHEMBL4734624 | 0.66 | RAD52 (0.45) | JAK2JAK1KMT2A | |
| SCHEMBL691603 | 0.65 | PRKCI (0.44) | JAK2PAK4RETLTKKDR | |
| SCHEMBL29700716 | 0.65 | PRKCI (0.44) | JAK2PAK4RETLTKKDR | |
| SCHEMBL311465 | 0.64 | MEN1 (0.47) | KDRJAK1ADORA2AADORA1PDGFRB | |
| SCHEMBL13666508 | 0.62 | PRKCI (0.41) | JAK2DYRK1AJAK1AXLPRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646423-A1 | NOVEL COMPOUNDS AS RESPIRATORY STIMULANTS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES | Galleon Pharmaceuticals, Inc. (US) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012074999-A1 | NOVEL COMPOUNDS AS RESPIRATORY STIMULANTS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES | GALLEON PHARMACEUTICALS, INC. (US) | 2012-06-07 | — | — | WO | disclosed |