Bromide

Bromide

SCHEMBL9286907

Br.CCOC(=O)[C@@H](C)[C@H](N)C(=O)O

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 2/20 0.44
ALOX15 P16050 1/20 0.39
SLC1A3 P43003 1/20 0.39
SLC1A2 P43004 1/20 0.39
SLC1A1 P43005 1/20 0.39
PIN1 Q13526 1/20 0.38
ALDH1A1 P00352 3/20 0.37
LMNA P02545 1/20 0.36
HSD17B10 Q99714 1/20 0.36
GABRP O00591 2/20 0.35
GABRD O14764 2/20 0.35
GABRA1 P14867 2/20 0.35
GABRB1 P18505 2/20 0.35
GABRG2 P18507 2/20 0.35
GABRB3 P28472 2/20 0.35
GABRA5 P31644 2/20 0.35
GABRA3 P34903 2/20 0.35
GABRA2 P47869 2/20 0.35
GABRB2 P47870 2/20 0.35
GABRA4 P48169 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12480857 0.80 ALDH1A1 (0.42) ALOX15PIN1ALDH1A1LMNAHSD17B10
SCHEMBL12480860 0.80 ALDH1A1 (0.42) ALOX15PIN1ALDH1A1LMNAHSD17B10
SCHEMBL15333919 0.80 ALDH1A1 (0.42) ALOX15PIN1ALDH1A1LMNAHSD17B10
SCHEMBL6009385 0.80 ALOX15 (0.44) SLC7A5ALOX15SLC1A3SLC1A2SLC1A1
SCHEMBL3020789 0.80 ALOX15 (0.48) ALOX15ALDH1A1LMNAHSD17B10GABRP
Bromide SCHEMBL9295467 0.78 SLC7A5 (0.48) SLC7A5SLC1A3SLC1A2SLC1A1KMT2A
Hydrochloric Acid SCHEMBL18230686 0.78 ALOX15 (0.46) ALOX15PIN1ALDH1A1LMNAHSD17B10
SCHEMBL4757436 0.78 ALDH1A1 (0.43) ALOX15PIN1ALDH1A1LMNAHSD17B10
SCHEMBL4757433 0.78 ALDH1A1 (0.43) ALOX15PIN1ALDH1A1LMNAHSD17B10
SCHEMBL15015691 0.78 ALDH1A1 (0.43) ALOX15PIN1ALDH1A1LMNAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0643710-A1 SYNTHESIS OF OPTICALLY ACTIVE LACTONES FROM L-ASPARTIC ACID AND INTERMEDIATES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1995-03-22 EP disclosed
WO-1992021675-A1 SYNTHESIS OF OPTICALLY ACTIVE LACTONES FROM L-ASPARTIC ACID AND INTERMEDIATES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1992-12-10 WO disclosed