Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 6/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 8/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5041371 | 1.00 | CHRNB4 (0.36) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM1 | |
| SCHEMBL5037373 | 0.90 | CHRNB2 (0.36) | CHRNB2CHRNA4CYP2D6 | |
| SCHEMBL5036656 | 0.88 | CHRNB2 (0.35) | CHRNB2CHRNA4CYP2D6 | |
| SCHEMBL5038413 | 0.87 | CHRNB2 (0.39) | CHRNB4CHRNA3CHRNB2CHRNA4POLB | |
| SCHEMBL5034210 | 0.87 | CHRNB2 (0.41) | CHRNB4CHRNA3CHRNB2CHRNA4CHRM1 | |
| SCHEMBL5038447 | 0.87 | CHRNB2 (0.38) | CHRNB4CHRNA3CHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL5038439 | 0.84 | CHRNB2 (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL5034038 | 0.84 | CYP2D6 (0.33) | CYP2D6 | |
| SCHEMBL5041551 | 0.83 | CHRNB2 (0.34) | CHRNB4CHRNA3CHRNB2CHRNA4POLB | |
| SCHEMBL5043607 | 0.83 | CHRNB2 (0.34) | CHRNB4CHRNA3CHRNB2CHRNA4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872010-B2 | Substituted diazabicycloalkane derivatives having affinity for nicotinic acetylcholine receptors | ABBOTT LABORATORIES (US) | 2011-01-18 | — | — | US | disclosed |
| US-20080275048-A1 | Substituted Diazabicycloalkane Derivates | ABBOTT LABORATORIES (US) | 2008-11-06 | — | — | US | disclosed |
| EP-1359152-B1 | Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands | ABBOTT LAB (US) | 2008-05-07 | — | — | EP | disclosed |
| US-7265115-B2 | Diazabicyclic CNS active agents | ABBOTT LABORATORIES (US) | 2007-09-04 | — | — | US | disclosed |
| US-20030225268-A1 | Diazabicyclic CNS active agents | ABBVIE INC. | 2003-12-04 | — | — | US | disclosed |
| EP-1359152-A2 | Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands | ABBOTT LABORATORIES (US) | 2003-11-05 | — | — | EP | disclosed |
| EP-1147112-B1 | DIAZABICYCLIC DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | ABBOTT LAB (US) | 2003-10-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275048-A1 | Substituted Diazabicycloalkane Derivates | CHRNA7, CHRNA1, CHRNA2 | CHRNB4 20/4885CHRNA3 8/4885CHRNB2 7/4885 |
| US-20030225268-A1 | Diazabicyclic CNS active agents | GABRE, GRIN1, CNTN1 | CHRNB4 37/4885CHRNA3 23/4885CHRNB2 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.