Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUMO3 | P55854 | 1/20 | 0.72 |
| ▸ | SUMO2 | P61956 | 1/20 | 0.72 |
| ▸ | SUMO1 | P63165 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | NPY1R | P25929 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | RAD52 | P43351 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | UBE2N | P61088 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4977971 | 0.84 | APP (0.63) | SUMO3SUMO2SUMO1KMT2AMEN1 | |
| SCHEMBL4980653 | 0.84 | KMT2A (0.59) | SUMO3SUMO2SUMO1KMT2AMEN1 | |
| SCHEMBL4864986 | 0.83 | PDE5A (0.64) | SUMO3SUMO2SUMO1KMT2AMEN1 | |
| SCHEMBL5238637 | 0.79 | KMT2A (0.54) | SUMO3SUMO2SUMO1KMT2AMEN1 | |
| SCHEMBL7687770 | 0.78 | SUMO3 (0.49) | SUMO3SUMO2SUMO1KMT2AMEN1 | |
| SCHEMBL7679071 | 0.78 | SUMO3 (0.49) | SUMO3SUMO2SUMO1KMT2AMEN1 | |
| SCHEMBL4864291 | 0.78 | KDM4E (0.53) | SUMO3SUMO2SUMO1KMT2AMEN1 | |
| SCHEMBL560210 | 0.77 | POLB (0.58) | SUMO3SUMO2SUMO1KMT2AMEN1 | |
| SCHEMBL11237247 | 0.77 | SMN1; SMN2 (1.00) | SUMO3SUMO2SUMO1KMT2AMEN1 | |
| SCHEMBL12175837 | 0.76 | RAD52 (1.00) | KMT2AMEN1MAPTKDM4ERAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572437-B1 | 2,4-DIAMINOQUINAZOLINES DERIVATIVES FOR ENHANCING ANTITUMOR ACTIVITY | PFIZER (US) | 1995-04-26 | — | — | EP | disclosed |