Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 7/20 | 0.45 |
| ▸ | TEK | Q02763 | 3/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11118273 | 0.89 | LMNA (0.57) | KMT2AMEN1NR1I2LMNACYP1A2 | |
| SCHEMBL928356 | 0.87 | LMNA (0.60) | KMT2AMEN1NR1I2LMNACYP1A2 | |
| SCHEMBL6029624 | 0.80 | LMNA (0.65) | KMT2AMEN1NR1I2LMNACYP1A2 | |
| SCHEMBL9791253 | 0.79 | LMNA (0.46) | KMT2AMEN1NR1I2LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL31436134 | 0.76 | TAAR1 (0.39) | KMT2AMEN1NR1I2LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL20610148 | 0.76 | TAAR1 (0.39) | KMT2AMEN1NR1I2LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL20610147 | 0.76 | TAAR1 (0.39) | KMT2AMEN1NR1I2LMNACYP1A2 | |
| SCHEMBL11839896 | 0.74 | MEN1 (0.37) | KMT2AMEN1NR1I2LMNACYP1A2 | |
| SCHEMBL8531423 | 0.74 | CYP1A2 (0.58) | KMT2AMEN1NR1I2LMNACYP1A2 | |
| SCHEMBL11842748 | 0.73 | CHEK2 (0.41) | KMT2AMEN1NR1I2LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7875727-B2 | methyl [5(6)-(4-alanylaminophenylthio)-1H-benzimidazol-2yl]carbamate; for treating neovascularization, solid tumors, macular degeneration, diabetic retinopathy, rheumatoid arthritis, psoriasis, and atherosclerosis | ANGIOGENE PHARMACEUTICALS LTD. (GB) | 2011-01-25 | — | — | US | disclosed |