Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 6/20 | 0.49 |
| ▸ | TEK | Q02763 | 4/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL928813 | 0.87 | KMT2A (0.52) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| SCHEMBL11118273 | 0.84 | LMNA (0.57) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| SCHEMBL6029536 | 0.81 | LMNA (0.77) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Hydrochloric Acid SCHEMBL31436134 | 0.76 | TAAR1 (0.39) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Hydrochloric Acid SCHEMBL20610147 | 0.76 | TAAR1 (0.39) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Hydrochloric Acid SCHEMBL20610148 | 0.76 | TAAR1 (0.39) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Fenbendazole SCHEMBL30384658 | 0.75 | LMNA (1.00) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| Fenbendazole SCHEMBL8469702 | 0.75 | LMNA (1.00) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| SCHEMBL9791253 | 0.75 | LMNA (0.46) | LMNACYP1A2MEN1KMT2ANR1I2 | |
| SCHEMBL8531423 | 0.74 | CYP1A2 (0.58) | LMNACYP1A2MEN1KMT2ANR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7875727-B2 | methyl [5(6)-(4-alanylaminophenylthio)-1H-benzimidazol-2yl]carbamate; for treating neovascularization, solid tumors, macular degeneration, diabetic retinopathy, rheumatoid arthritis, psoriasis, and atherosclerosis | ANGIOGENE PHARMACEUTICALS LTD. (GB) | 2011-01-25 | — | — | US | disclosed |