Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31260109 | 0.85 | HTT (0.38) | SMN1; SMN2HTTMAPTHCRTR1HCRTR2 | |
| SCHEMBL749371 | 0.85 | HTT (0.38) | SMN1; SMN2HTTMAPTHCRTR1HCRTR2 | |
| SCHEMBL3121276 | 0.79 | ALDH1A1 (0.48) | HTTMAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL3723569 | 0.78 | CHRNB2 (0.47) | SMN1; SMN2HTTMAPTKDM4EPOLB | |
| SCHEMBL1606271 | 0.77 | HTT (0.39) | SMN1; SMN2HTTMAPTHCRTR1HCRTR2 | |
| SCHEMBL14780006 | 0.75 | MAPT (0.38) | SMN1; SMN2HTTMAPTHCRTR1HCRTR2 | |
| SCHEMBL3709551 | 0.75 | HTT (0.39) | SMN1; SMN2HTTMAPTKDM4EPOLB | |
| SCHEMBL16619456 | 0.73 | POLB (0.44) | SMN1; SMN2HTTMAPTKDM4EPOLB | |
| SCHEMBL14778861 | 0.73 | MAPT (0.36) | SMN1; SMN2HTTMAPTHCRTR1HCRTR2 | |
| SCHEMBL14297420 | 0.73 | TSHR (0.50) | HTTKDM4EAPLNRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109843879-B | Benzothiazole derivatives as DYRK1 inhibitors | 药物治疗股份有限公司 | 2023-05-02 | — | — | CN | disclosed |
| WO-1995028400-A1 | NOVEL BENZOFUSED 5-MEMBERED HETEROCYCLIC RINGS FOR THE TREATMENT OF MIGRAINE | GLAXO GROUP LIMITED (GB) | 1995-10-26 | — | — | WO | disclosed |