SCHEMBL9290407

SCHEMBL9290407

CN1C(=O)c2cccc3c(I)ccc1c23

nearest known ligand 0.60

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PKM P14618 3/20 0.57
BRD4 O60885 11/20 0.53
ALDH1A1 P00352 3/20 0.49
KDM4E B2RXH2 2/20 0.49
MEN1 O00255 1/20 0.49
USP2 O75604 1/20 0.49
KMT2A Q03164 1/20 0.49
ATM Q13315 1/20 0.49
KEAP1 Q14145 1/20 0.49
NFE2L2 Q16236 1/20 0.49
HPGD P15428 1/20 0.49
SMN1; SMN2 Q16637 2/20 0.48
LMNA P02545 1/20 0.47
TP53 P04637 1/20 0.47
POLB P06746 1/20 0.47
CASP1 P29466 1/20 0.47
TDP1 Q9NUW8 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12561181 0.81 PKM (0.58) PKMBRD4ALDH1A1KDM4EMEN1
SCHEMBL9078889 0.80 USP2 (0.76) PKMBRD4ALDH1A1KDM4EMEN1
SCHEMBL30517121 0.80 PKM (0.57) PKMBRD4ALDH1A1KDM4EMEN1
SCHEMBL12561180 0.80 PKM (0.57) PKMBRD4ALDH1A1KDM4EMEN1
SCHEMBL9290413 0.80 PKM (0.57) PKMBRD4ALDH1A1KDM4EMEN1
SCHEMBL9290438 0.80 PKM (0.53) PKMBRD4ALDH1A1KDM4EMEN1
SCHEMBL20097979 0.79 KMT2A (0.51) PKMALDH1A1KDM4EMEN1USP2
SCHEMBL9290421 0.78 KDM4E (0.68) PKMBRD4ALDH1A1KDM4EMEN1
SCHEMBL9290425 0.78 PRMT1 (0.77) PKMBRD4ALDH1A1KDM4EMEN1
SCHEMBL21336041 0.78 PKM (0.55) PKMBRD4ALDH1A1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8350054-B2 Optical filter ADEKA CORPORATION (JP) 2013-01-08 US disclosed
US-8350054-B2 Optical filter ADEKA CORPORATION (JP) 2013-01-08 US disclosed
EP-2458941-A1 OPTICAL FILTER Adeka Corporation (JP) 2012-05-30 EP disclosed
US-20110152538-A1 OPTICAL FILTER ADEKA CORPORATION (JP) 2011-06-23 US disclosed
US-20110152538-A1 OPTICAL FILTER ADEKA CORPORATION (JP) 2011-06-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110152538-A1 OPTICAL FILTER C1R, CBR3, CBR1 PKM 1698/4885BRD4 3880/4885ALDH1A1 776/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.