SCHEMBL9290449

SCHEMBL9290449

O=C1c2cccc3c(-c4ccc(Sc5ccccc5)cc4)ccc(c23)N1Cc1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1B1 Q16678 5/20 0.51
MAPT P10636 4/20 0.51
LMNA P02545 2/20 0.51
MEN1 O00255 2/20 0.51
HTT P42858 2/20 0.51
KMT2A Q03164 2/20 0.51
RGS12 O14924 1/20 0.51
USP2 O75604 1/20 0.51
RECQL P46063 1/20 0.51
NPSR1 Q6W5P4 3/20 0.48
L3MBTL1 Q9Y468 2/20 0.43
ALDH1A1 P00352 5/20 0.43
ALDH2 P05091 2/20 0.43
ALDH3A1 P30838 2/20 0.43
CHRM1 P11229 1/20 0.43
CES1 P23141 1/20 0.43
UBE2N P61088 2/20 0.43
HPGD P15428 1/20 0.43
ATM Q13315 1/20 0.43
TDP1 Q9NUW8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9290377 0.89 CYP1B1 (0.59) CYP1B1MAPTLMNAMEN1HTT
SCHEMBL12561342 0.86 MAPT (0.53) CYP1B1MAPTLMNAMEN1HTT
SCHEMBL9290458 0.84 MAPT (0.39) CYP1B1MAPTLMNAMEN1HTT
SCHEMBL9290350 0.84 MAPT (0.51) CYP1B1MAPTLMNAMEN1HTT
SCHEMBL9290472 0.83 KDM4E (0.56) CYP1B1MAPTLMNAMEN1HTT
SCHEMBL9290418 0.83 CHRM5 (0.53) CYP1B1MAPTLMNAMEN1HTT
SCHEMBL9290451 0.82 ALDH1A1 (0.41) MAPTMEN1HTTKMT2ANPSR1
SCHEMBL9290456 0.82 KEAP1 (0.51) CYP1B1MAPTMEN1HTTKMT2A
SCHEMBL12561379 0.81 CYP1A2 (0.39) CYP1B1MAPTMEN1HTTKMT2A
SCHEMBL9290459 0.81 MAPT (0.43) CYP1B1MAPTMEN1HTTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8350054-B2 Optical filter ADEKA CORPORATION (JP) 2013-01-08 US disclosed
US-8350054-B2 Optical filter ADEKA CORPORATION (JP) 2013-01-08 US disclosed
EP-2458941-A1 OPTICAL FILTER Adeka Corporation (JP) 2012-05-30 EP disclosed
US-20110152538-A1 OPTICAL FILTER ADEKA CORPORATION (JP) 2011-06-23 US disclosed
US-20110152538-A1 OPTICAL FILTER ADEKA CORPORATION (JP) 2011-06-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110152538-A1 OPTICAL FILTER C1R, CBR3, CBR1 CYP1B1 752/4885MAPT 4299/4885LMNA 1475/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.