Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Duvoglustat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 6/20 | 1.00 |
| ▸ | GLA known ✓ | P06280 | 4/20 | 1.00 |
| ▸ | FUCA1 | P04066 | 4/20 | 1.00 |
| ▸ | MGAM | O43451 | 4/20 | 1.00 |
| ▸ | GBA2 | Q9HCG7 | 3/20 | 1.00 |
| ▸ | SI | P14410 | 3/20 | 1.00 |
| ▸ | AGL | P35573 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | GBA1 | P04062 | 2/20 | 1.00 |
| ▸ | LCT | P09848 | 2/20 | 1.00 |
| ▸ | GBA3 | Q9H227 | 2/20 | 1.00 |
| ▸ | MAN2B1 | O00754 | 1/20 | 1.00 |
| ▸ | MAN2B2 | Q9Y2E5 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | TREH | O43280 | 1/20 | 1.00 |
| ▸ | GANAB | Q14697 | 1/20 | 1.00 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Duvoglustat SCHEMBL13298786 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL4619759 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL15896653 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL142573 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL10028910 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL12269503 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL24518227 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL2163281 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL13061461 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL21104989 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230348388-A1 | Highly Purified Batches Of Pharmaceutical Grade Migalastat And Methods Of Producing The Same | AMICUS THERAPEUTICS, INC. (US) | 2023-11-02 | — | — | US | disclosed |
| US-11685912-B2 | Affinity purification of glycosidase-cleaving enzymes | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-06-27 | — | — | US | disclosed |
| US-11685718-B2 | Highly purified batches of pharmaceutical grade 1-deoxygalactonojirimycin compounds | AMICUS THERAPEUTICS, INC. (US) | 2023-06-27 | — | — | US | disclosed |
| US-20220194899-A1 | HIGHLY PURIFIED BATCHES OF PHARMACEUTICAL GRADE 1-DEOXYGALACTONOJIRIMYCIN COMPOUNDS | AMICUS THERAPEUTICS, INC. (US) | 2022-06-23 | — | — | US | disclosed |
| US-20220184185-A1 | MRNA BASED ENZYME REPLACEMENT THERAPY COMBINED WITH A PHARMACOLOGICAL CHAPERONE FOR THE TREATMENT OF LYSOSOMAL STORAGE DISORDERS | MODERNATX, INC. | 2022-06-16 | — | — | US | disclosed |
| US-20220062254-A1 | INHIBITORS OF GANGLIOSIDES METABOLISM FOR THE TREATMENT OF MOTOR NEURON DISEASES | ICM INST DU CERVEAU ET DE LA MOELLE EPINIERE (FR) | 2022-03-03 | — | — | US | disclosed |
| US-11065238-B2 | Inhibitors of gangliosides metabolism for the treatment of motor neuron diseases | ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE) (FR) | 2021-07-20 | — | — | US | disclosed |
| US-11033538-B2 | Dosing regimens for the treatment of lysosomal storage diseases using pharmacological chaperones | AMICUS THERAPEUTICS, INC. (US) | 2021-06-15 | — | — | US | disclosed |
| US-20210040465-A1 | AFFINITY PURIFICATION OF GLYCOSIDE-CLEAVING ENZYMES | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2021-02-11 | — | — | US | disclosed |
| US-20190350913-A1 | INHIBITORS OF GANGLIOSIDES METABOLISM FOR THE TREATMENT OF MOTOR NEURON DISEASES | ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE) (FR) | 2019-11-21 | — | — | US | disclosed |
| EP-2435459-B1 | UTILIZATION OF PHARMACOLOGICAL CHAPERONES TO IMPROVE MANUFACTURING AND PURIFICATION OF ACID BETA-GLUCOSIDASE | AMICUS THERAPEUTICS INC (US) | 2016-05-04 | — | — | EP | disclosed |
| US-20120220632-A1 | Methods For Treatment of Fabry Disease | AMICUS THERAPEUTICS, INC. (US) | 2012-08-30 | — | — | US | disclosed |
| WO-2012071451-A2 | UTILIZATION OF PHARMACOLOGICAL CHAPERONES TO IMPROVE MANUFACTURING AND PURIFICATION OF BIOLOGICS | AMICUS THERAPEUTICS, INC. (US) | 2012-05-31 | — | — | WO | disclosed |
| US-20110212996-A1 | METHOD TO PREDICT RESPONSE TO PHARMACOLOGICAL CHAPERONE TREATMENT OF DISEASES | AMICUS THERAPEUTICS, INC. (US) | 2011-09-01 | — | — | US | disclosed |
| US-20110152319-A1 | METHOD TO PREDICT RESPONSE TO PHARMACOLOGICAL CHAPERONE TREATMENT OF DISEASES | AMICUS THERAPEUTICS, INC. (US) | 2011-06-23 | — | — | US | disclosed |
| US-20110143419-A1 | Utilization of Pharmacological Chaperones to Improve Manufacturing and Purification of Biologics | AMICUS THERAPEUTICS, INC. | 2011-06-16 | — | — | US | disclosed |
| US-20110104727-A1 | ASSAYS FOR DIAGNOSING AND EVALUATING TREATMENT OPTIONS FOR FABRY DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-05-05 | — | — | US | disclosed |
| US-20110070643-A1 | Utilization of Pharmacological Chaperones to Improve Manufacturing and Purification of Biologics | AMICUS THERAPEUTICS, INC. | 2011-03-24 | — | — | US | disclosed |
| US-7851143-B2 | Assays for diagnosing and evaluating treatment options for Fabry disease | AMICUS THERAPEUTICS, INC. (US) | 2010-12-14 | — | — | US | disclosed |
| US-20080056994-A1 | Assays For Diagnosing And Evaluating Treatment Options For Fabry Disease | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152319-A1 | METHOD TO PREDICT RESPONSE TO PHARMACOLOGICAL CHAPERONE TREATMENT OF DISEASES | MAN2B1, GAA, GBA1 | GAA 2/4885GLA 12/4885FUCA1 24/4885 |
| US-20230348388-A1 | Highly Purified Batches Of Pharmaceutical Grade Migalastat And Methods Of Producing The Same | GANAB, GALK1, GANC | GAA 6/4885GLA 5/4885FUCA1 1919/4885 |
| US-20080056994-A1 | Assays For Diagnosing And Evaluating Treatment Options For Fabry Disease | GAA, GBA1, MAN2B1 | GAA 1/4885GLA 26/4885FUCA1 156/4885 |
| US-11065238-B2 | Inhibitors of gangliosides metabolism for the treatment of motor neuron diseases | GBA1, SMN1; SMN2, GAA | GAA 3/4885GLA 604/4885FUCA1 1203/4885 |
| US-11033538-B2 | Dosing regimens for the treatment of lysosomal storage diseases using pharmacological chaperones | HSPA5, MAN2B1, GBA1 | GAA 5/4885GLA 328/4885FUCA1 439/4885 |
| US-20190350913-A1 | INHIBITORS OF GANGLIOSIDES METABOLISM FOR THE TREATMENT OF MOTOR NEURON DISEASES | GBA1, SMN1; SMN2, GAA | GAA 3/4885GLA 604/4885FUCA1 1203/4885 |
| US-20110212996-A1 | METHOD TO PREDICT RESPONSE TO PHARMACOLOGICAL CHAPERONE TREATMENT OF DISEASES | MAN2B1, GAA, GBA1 | GAA 2/4885GLA 12/4885FUCA1 24/4885 |
| US-11685718-B2 | Highly purified batches of pharmaceutical grade 1-deoxygalactonojirimycin compounds | GALK1, GANAB, MGAM | GAA 12/4885GLA 6/4885FUCA1 1336/4885 |
| US-20220194899-A1 | HIGHLY PURIFIED BATCHES OF PHARMACEUTICAL GRADE 1-DEOXYGALACTONOJIRIMYCIN COMPOUNDS | GALK1, GANAB, MGAM | GAA 12/4885GLA 6/4885FUCA1 1336/4885 |
| US-20120220632-A1 | Methods For Treatment of Fabry Disease | GAA, HSP90B1, GBA1 | GAA 1/4885GLA 17/4885FUCA1 118/4885 |
| US-20220062254-A1 | INHIBITORS OF GANGLIOSIDES METABOLISM FOR THE TREATMENT OF MOTOR NEURON DISEASES | GBA1, SMN1; SMN2, GAA | GAA 3/4885GLA 604/4885FUCA1 1203/4885 |
| US-20220184185-A1 | MRNA BASED ENZYME REPLACEMENT THERAPY COMBINED WITH A PHARMACOLOGICAL CHAPERONE FOR THE TREATMENT OF LYSOSOMAL STORAGE DISORDERS | GAA, GBA1, GBA2 | GAA 1/4885GLA 9/4885FUCA1 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.