Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.36 |
| ▸ | HPGD | P15428 | 6/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9288685 | 0.78 | ALDH1A1 (0.43) | LMNAALDH1A1HPGDGAAKDM4E | |
| SCHEMBL17342569 | 0.72 | ALDH1A1 (0.48) | ALDH1A1HPGDGAAKDM4EADORA1 | |
| SCHEMBL14310461 | 0.71 | LMNA (0.46) | LMNAALDH1A1HPGDGAAKDM4E | |
| SCHEMBL31575894 | 0.69 | ALDH1A1 (0.55) | ALDH1A1HPGDGAAKDM4EADORA1 | |
| SCHEMBL17401071 | 0.69 | ADORA1 (0.38) | LMNAALDH1A1HPGDGAAKDM4E | |
| SCHEMBL11900926 | 0.69 | ALDH1A1 (0.55) | ALDH1A1HPGDGAAKDM4EADORA1 | |
| SCHEMBL18300545 | 0.69 | KDM4E (0.39) | ALDH1A1HPGDGAAKDM4EADORA1 | |
| SCHEMBL9289563 | 0.68 | LMNA (0.52) | LMNAALDH1A1HPGDGAAKDM4E | |
| SCHEMBL18868083 | 0.67 | HTT (0.37) | LMNAALDH1A1HPGDGAAKDM4E | |
| SCHEMBL15429586 | 0.67 | ALDH1A1 (0.37) | LMNAALDH1A1HPGDGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012071501-A1 | BENZOXAZEPINES ASN INHIBITORS OF P13K/M TOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-05-31 | — | — | WO | disclosed |