Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL9291323

COc1ccc(C2C3=CC=C2C=C3)c(OC)c1.N

nearest known ligand 0.54

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.49
CA2 P00918 3/20 0.47
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
CA7 P43166 1/20 0.47
CA9 Q16790 1/20 0.47
CA14 Q9ULX7 1/20 0.47
CYP1A1 P04798 4/20 0.46
CYP1A2 P05177 4/20 0.46
CYP1B1 Q16678 4/20 0.46
CYP3A4 P08684 2/20 0.46
CYP2E1 P05181 1/20 0.46
CYP2C8 P10632 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2A6 P11509 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP4B1 P13584 1/20 0.46
CYP2B6 P20813 1/20 0.46
CYP3A5 P20815 1/20 0.46
CYP2A7 P20853 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31172738 0.71 MEN1 (0.58) ALDH1A1CA2CA12CA1CA7
SCHEMBL25705273 0.71 MEN1 (0.54) ALDH1A1CA2CA12CA1CA7
SCHEMBL3692141 0.71 MEN1 (0.58) ALDH1A1CA2CA12CA1CA7
SCHEMBL23268487 0.71 MEN1 (0.58) ALDH1A1CA2CA12CA1CA7
SCHEMBL30360992 0.71 CYP3A4 (0.59) ALDH1A1CA2CA12CA1CA7
SCHEMBL23268494 0.71 MEN1 (0.54) ALDH1A1CA2CA12CA1CA7
Ammonia Solution, Strong SCHEMBL266622 0.70 MEN1 (0.50) ALDH1A1CA2CA12CA1CA7
SCHEMBL10841566 0.69 ALDH1A1 (0.55) ALDH1A1CA2CA12CA1CA7
SCHEMBL28313771 0.69 CYP3A4 (0.46) ALDH1A1CA2CA12CA1CA7
SCHEMBL28313772 0.69 NR3C1 (0.48) ALDH1A1CA2CA12CA1CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5364851-A Internal coupling/cyclization to form helical structures INTERNATIONAL SYNTHECON, LLC (US) 1994-11-15 US disclosed