Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | FADS1 | O60427 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | PNPLA2 | Q96AD5 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11716429 | 0.87 | APEX1 (0.55) | TP53APEX1PNPLA2HDAC6MEN1 | |
| SCHEMBL11409020 | 0.84 | MEN1 (0.55) | FADS1MEN1KMT2ACA2MTOR | |
| SCHEMBL19019393 | 0.84 | TP53 (0.69) | TP53APEX1PNPLA2HDAC6 | |
| SCHEMBL11163949 | 0.83 | TP53 (0.50) | TP53APEX1PNPLA2HDAC6MEN1 | |
| SCHEMBL7634431 | 0.83 | TP53 (0.56) | TP53APEX1PNPLA2HDAC6MEN1 | |
| SCHEMBL104492 | 0.81 | ALDH1A1 (0.59) | TP53FADS1MEN1KMT2ACA2 | |
| SCHEMBL2096083 | 0.81 | FADS1 (0.59) | TP53FADS1MEN1KMT2ACA2 | |
| SCHEMBL2096086 | 0.81 | FADS1 (0.59) | FADS1MEN1KMT2ACA2MTOR | |
| SCHEMBL16980501 | 0.80 | KDM4E (0.51) | FADS1MEN1KMT2ACA2GRIN2D | |
| SCHEMBL12569599 | 0.79 | FADS1 (0.61) | FADS1MEN1KMT2ACA2GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230312576-A1 | 4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER | UNIVERSITÉ DE TOURS (FR) | 2023-10-05 | — | — | US | disclosed |
| US-5321000-A | Benzhydryl compounds as herbicide antidotes | MONSANTO COMPANY (US) | 1994-06-14 | — | — | US | disclosed |
| US-5162537-A | To safen acetamide herbicids used to control grassy and broadleaf weeds in rice, sorghum and wheat | MONSANTO COMPANY (US) | 1992-11-10 | — | — | US | disclosed |
| US-4964893-A | REDUCING INJURY TO A CROP PLANT | MONSANTO COMPANY (US) | 1990-10-23 | — | — | US | disclosed |
| US-4740236-A | N-sulfonyl-imino-thiocarbonic acid diesters as herbicide antagonists for the protection of rice crops | CIBA-GEIGY CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4674229-A | SEEDS COATED WITH PLANT SAFENING AGENT | CIBA-GEIGY CORPORATION (US) | 1987-06-23 | — | — | US | disclosed |
| US-4648896-A | PLANT SAFENING AGENTS | CIBA-GEIGY CORPORATION (US) | 1987-03-10 | — | — | US | disclosed |
| US-4493726-A | PLANT SAFENING AGENT | CIBA GEIGY CORPORATION (US) | 1985-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230312576-A1 | 4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER | LIMK1, LIMK2, ROCK1 | TP53 2381/4885FADS1 3683/4885APEX1 2442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.