Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TACR1 | P25103 | 6/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27298881 | 1.00 | SLC6A2 (0.50) | SLC6A2SLC6A4CYP2D6CYP3A4CYP1A2 | |
| SCHEMBL7654723 | 1.00 | SLC6A2 (0.50) | SLC6A2SLC6A4CYP2D6CYP3A4CYP1A2 | |
| SCHEMBL8262931 | 0.91 | SLC6A2 (0.49) | SLC6A2SLC6A4CYP2D6CYP3A4CYP1A2 | |
| SCHEMBL16280635 | 0.85 | MAPT (0.56) | SLC6A2SLC6A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL11766426 | 0.85 | MAPT (0.56) | SLC6A2SLC6A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL20321224 | 0.85 | MAPT (0.56) | SLC6A2SLC6A4CYP2D6CYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL28377112 | 0.85 | SLC6A3 (0.43) | SLC6A2SLC6A4TACR1SLC6A3 | |
| SCHEMBL12160757 | 0.85 | MAPT (0.56) | SLC6A2SLC6A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL13002585 | 0.83 | ADAM10 (0.42) | SLC6A2SLC6A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL16579321 | 0.83 | MEN1 (0.50) | CYP2D6CYP3A4CYP1A2CYP2C19TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436334-B1 | 3-Aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER (US) | 1994-12-07 | — | — | EP | disclosed |
| US-5332817-A | 3-aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER INC. (US) | 1994-07-26 | — | — | US | disclosed |
| US-5232929-A | 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use | PFIZER INC. (US) | 1993-08-03 | — | — | US | disclosed |
| WO-1991009844-A1 | SUBSTANCE P ANTAGONISTS | PFIZER INC. (US) | 1991-07-11 | — | — | WO | disclosed |
| EP-0436334-A2 | 3-Aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER INC. (US) | 1991-07-10 | — | — | EP | disclosed |