Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.58 |
| ▸ | RAB9A | P51151 | 9/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13304158 | 0.88 | NPC1 (0.60) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL507865 | 0.86 | NPC1 (0.58) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL6226380 | 0.82 | NPC1 (0.63) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL9379929 | 0.82 | KMT2A (0.57) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL2923680 | 0.80 | NPC1 (0.65) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL3779866 | 0.80 | TAS1R3 (0.53) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL24746236 | 0.79 | NPC1 (0.63) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL4598068 | 0.77 | NPC1 (0.64) | NPC1RAB9AHPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL3134481 | 0.76 | KMT2A (0.60) | NPC1RAB9AHPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL507568 | 0.76 | RAB9A (0.62) | NPC1RAB9AHPGDSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344414-B1 | 5-Substitued imidazo[4,5-c]pyridines | SEARLE & CO (US) | 1994-10-12 | — | — | EP | disclosed |
| US-5302601-A | Useful in the treatment of diseases mediated by platelet activating factor | G. D. SEARLE & CO. (US) | 1994-04-12 | — | — | US | disclosed |
| US-5227384-A | Platelet activating factor antagonist | G. D. SEARLE & CO. (US) | 1993-07-13 | — | — | US | disclosed |
| US-5019581-A | 5-substituted (4,5-c) imidazopyridine compounds which have useful platelet activating factor antagonistic activity | G. D. SEARLE & CO. (US) | 1991-05-28 | — | — | US | disclosed |
| US-4914108-A | TREATMENT OF INFLAMMATION, RESPIRATORY SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS | G. D. SEARLE & CO. (US) | 1990-04-03 | — | — | US | disclosed |
| EP-0344414-A1 | 5-Substitued imidazo[4,5-c]pyridines | G.D. Searle & Co. (US) | 1989-12-06 | — | — | EP | disclosed |