Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 15/20 | 0.63 |
| ▸ | CTSB | P07858 | 1/20 | 0.56 |
| ▸ | REN | P00797 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9296051 | 1.00 | CTSD (0.63) | CTSDCTSBRENOPRM1OPRD1 | |
| SCHEMBL7844670 | 0.95 | CTSD (0.61) | CTSDCTSBREN | |
| SCHEMBL11061687 | 0.85 | CTSD (0.57) | CTSDCTSBOPRM1OPRD1 | |
| SCHEMBL11061679 | 0.85 | CTSD (0.57) | CTSDCTSBOPRM1OPRD1 | |
| SCHEMBL30599230 | 0.84 | CTSD (0.56) | CTSDCTSB | |
| SCHEMBL38662780 | 0.84 | CTSD (0.58) | CTSDCTSBOPRM1OPRD1 | |
| SCHEMBL30536325 | 0.83 | CTSB (0.62) | CTSDCTSBOPRM1OPRD1 | |
| SCHEMBL30259423 | 0.83 | CTSD (0.50) | CTSDRENOPRM1OPRD1 | |
| SCHEMBL14164206 | 0.82 | CTSD (0.57) | CTSDCTSBRENOPRM1OPRD1 | |
| SCHEMBL29876711 | 0.82 | ACE (0.58) | CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557768-B1 | Human nerve growth factor by recombinant technology | GENENTECH, INC. (US) | 2013-10-15 | — | — | US | disclosed |
| US-5288622-A | Genetic engineering the DNA expression in host cell with the vectors encoded a human polypeptide | GENENTECH, INC. (US) | 1994-02-22 | — | — | US | disclosed |
| US-5169762-A | Human nerve growth factor by recombinant technology | GENENTECH, INC. (US) | 1992-12-08 | — | — | US | disclosed |
| EP-0121338-A1 | Biosynthetically produced human nerve growth factor, process for producing it, compositions containing it, DNA sequence encoding it, vectors containing the sequence and host cells transformed thereby | GENENTECH, INC. (US) | 1984-10-10 | — | — | EP | disclosed |