Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 4/20 | 0.35 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31378718 | 1.00 | HTR7 (0.52) | HTR7MAOAMAOBLMNACA1 | |
| SCHEMBL7974171 | 0.82 | MEN1 (0.37) | HTR7MAOAMAOBLMNAALDH1A1 | |
| SCHEMBL13508978 | 0.80 | HTR7 (0.67) | HTR7MAOAMAOBLMNACA1 | |
| SCHEMBL5663275 | 0.79 | HTR7 (0.55) | HTR7MAOAMAOBLMNACA1 | |
| SCHEMBL28754182 | 0.76 | HTR7 (0.52) | HTR7MAOAMAOBLMNACA1 | |
| SCHEMBL14460773 | 0.76 | HTR7 (0.62) | HTR7MAOAMAOBLMNACA1 | |
| SCHEMBL1802193 | 0.76 | HTR7 (0.57) | HTR7MAOAMAOBLMNACA1 | |
| SCHEMBL8779744 | 0.75 | HTR7 (0.32) | HTR7MAOAMAOBALDH1A1TAAR1 | |
| SCHEMBL28941890 | 0.74 | MEN1 (0.36) | HTR7MAOAMAOBCA1CA2 | |
| SCHEMBL4334230 | 0.73 | POLB (0.61) | HTR7MAOAMAOBLMNACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276053-A | Dibenzothiopyranylamines | WARNER-LAMBERT COMPANY (US) | 1994-01-04 | — | — | US | disclosed |
| US-5180736-A | Treatment and prevention of brain disorders | WARNER-LAMBERT COMPANY (US) | 1993-01-19 | — | — | US | disclosed |
| US-5071853-A | Amine-substituted hexahydroindeno(2,1-b)pyrroles, -indeno(2,1-c)pyridines or -indeno(2,1-d)azepines; cerebral ischemia or infarction | WARNER-LAMBERT COMPANY | 1991-12-10 | — | — | US | disclosed |
| EP-0388977-A2 | Polycyclic amines useful as cerebrovascular agents | WARNER-LAMBERT COMPANY (US) | 1990-09-26 | — | — | EP | disclosed |
| US-4062846-A | CNS STIMULANTS, MUSCLE RELAXANT | E. R. SQUIBB & SONS, INC. (US) | 1977-12-13 | — | — | US | disclosed |
| US-3995042-A | MUSCLE RELAXANTS, CENTRAL NERVOUS SYSTEM STIMULANTS | E. R. SQUIBB & SONS, INC. (US) | 1976-11-30 | — | — | US | disclosed |
| US-3981886-A | Amino-benzimidazole derivatives | E. R. SQUIBB & SONS, INC. (US) | 1976-09-21 | — | — | US | disclosed |
| US-3966733-A | CENTRAL NERVOUS SYSTEM STIMULANTS, MUSCLE RELAXANTS | E. R. SQUIBB & SONS, INC. (US) | 1976-06-29 | — | — | US | disclosed |
| US-3957799-A | STIMULANTS, MUSCLE RELAXANTS | E. R. SQUIBB & SONS, INC. (US) | 1976-05-18 | — | — | US | disclosed |
| US-3946025-A | MUSCLE RELAXANTS | E. R. SQUIBB & SONS, INC. (US) | 1976-03-23 | — | — | US | disclosed |