Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 16/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9297364 | 0.84 | POLB (0.56) | PTPN11SMN1; SMN2POLBKDM4ENPSR1 | |
| SCHEMBL14626136 | 0.84 | MAPT (0.56) | PTPN11SMN1; SMN2POLBKDM4ENPC1 | |
| SCHEMBL27316944 | 0.83 | POLB (0.55) | PTPN11SMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL9048339 | 0.80 | POLB (0.51) | PTPN11SMN1; SMN2POLBKDM4ENPSR1 | |
| SCHEMBL9051143 | 0.80 | POLB (0.51) | PTPN11SMN1; SMN2POLBKDM4ENPSR1 | |
| SCHEMBL15341329 | 0.76 | MAPT (0.53) | SMN1; SMN2POLBKDM4ENPC1RAB9A | |
| SCHEMBL10324214 | 0.75 | POLB (0.45) | SMN1; SMN2POLBKDM4ENPC1RAB9A | |
| SCHEMBL23370098 | 0.74 | MAPT (0.54) | SMN1; SMN2POLBKDM4ENPC1RAB9A | |
| SCHEMBL10322693 | 0.74 | PTPN11 (0.56) | PTPN11SMN1; SMN2POLBKDM4ENPC1 | |
| SCHEMBL30468126 | 0.74 | TSHR (0.47) | SMN1; SMN2KDM4ENPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0305184-B1 | Pyrimidines or their pharmaceutically acceptable salts thereof | MITSUI PHARMACEUTICALS (JP) | 1994-04-27 | — | — | EP | disclosed |
| US-5304555-A | Pyrimidines and pharmaceutically acceptable salts thereof useful in treatment of neurological disorders | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| WO-1989001938-A1 | PYRIMIDINES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | MITSUI PHARMACEUTICALS, INC. (JP) | 1989-03-09 | — | — | WO | disclosed |