Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9051143 | 0.87 | POLB (0.51) | POLBSMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL9297364 | 0.81 | POLB (0.56) | POLBSMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL1018213 | 0.81 | KDM4E (0.45) | POLBMAPTALDH1A1KDM4E | |
| SCHEMBL27316944 | 0.80 | POLB (0.55) | POLBSMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL9299149 | 0.80 | PTPN11 (0.60) | POLBSMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL28082063 | 0.79 | MAPT (0.54) | POLBSMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL17786852 | 0.76 | KLKB1 (0.57) | — | |
| SCHEMBL15341329 | 0.73 | MAPT (0.53) | POLBSMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL25260381 | 0.72 | MAPT (0.48) | POLBSMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL17786853 | 0.72 | F11 (0.40) | POLBSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0379806-B1 | Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines | MITSUI PETROCHEMICAL IND (JP) | 1996-04-10 | — | — | EP | disclosed |
| EP-0612746-A1 | Pyrimidines and their pharmaceutical acceptable salts and their use as medicines | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1994-08-31 | — | — | EP | disclosed |
| US-5264435-A | Treatment of neurological diseases | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1993-11-23 | — | — | US | disclosed |
| US-5147876-A | Nervous system disorders | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-09-15 | — | — | US | disclosed |
| EP-0379806-A2 | Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1990-08-01 | — | — | EP | disclosed |