Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL504667 | 0.82 | PLG (0.44) | PLGNOS3NOS1NOS2 | |
| SCHEMBL504588 | 0.82 | PLG (0.44) | PLGNOS3NOS1NOS2 | |
| SCHEMBL504564 | 0.76 | PLG (0.41) | PLGNOS3NOS1NOS2 | |
| SCHEMBL8200238 | 0.75 | PLG (0.40) | PLGNOS3NOS1NOS2KDM4E | |
| SCHEMBL8200233 | 0.72 | CYP17A1 (0.45) | PLGNOS3NOS1NOS2 | |
| SCHEMBL6759036 | 0.72 | SMN1; SMN2 (0.44) | SLC6A2KDM4E | |
| SCHEMBL6697781 | 0.71 | HRH1 (0.45) | PLG | |
| SCHEMBL8218501 | 0.70 | PLG (0.36) | PLGNOS3NOS1NOS2KDM4E | |
| SCHEMBL8218500 | 0.69 | CYP17A1 (0.36) | PLGNOS3NOS1NOS2 | |
| SCHEMBL9299300 | 0.69 | BCHE (0.36) | SLC6A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278169-A | Method of treating or prevention of fibrillation of the heart | E. R. SQUIBB & SONS, INC. (US) | 1994-01-11 | — | — | US | disclosed |
| US-5011837-A | Aryl cyanoguanidines: potassium channel activators and method of making same | E. R. SQUIBB & SONS, INC. (US) | 1991-04-30 | — | — | US | disclosed |
| EP-0354553-A2 | Aryl cyanoguanidines: potassium channel activators and method of making same | E.R. SQUIBB & SONS, INC. (US) | 1990-02-14 | — | — | EP | disclosed |