Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 4/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.39 |
| ▸ | CHRNG | P07510 | 1/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19321959 | 0.87 | HTR7 (0.49) | HTR7TLR8TLR7NAMPTHDAC4 | |
| SCHEMBL12218002 | 0.84 | HTR7 (0.47) | HTR7TLR8TLR7NAMPTHDAC4 | |
| SCHEMBL7884002 | 0.84 | HPGD (0.49) | TLR8TLR7HDAC4HTTHPGD | |
| SCHEMBL847739 | 0.84 | HPGD (0.45) | TLR8TLR7HDAC4HTTALDH1A1 | |
| SCHEMBL19354603 | 0.83 | HTR7 (0.47) | HTR7TLR8TLR7NAMPTHDAC4 | |
| SCHEMBL9300210 | 0.81 | PDK2 (0.47) | NAMPTHDAC4ALDH1A1HPGD | |
| SCHEMBL7882856 | 0.81 | HPGD (0.43) | TLR8TLR7HDAC4HTTALDH1A1 | |
| SCHEMBL19354779 | 0.81 | TLR8 (0.51) | HTR7TLR8TLR7NAMPTHDAC4 | |
| SCHEMBL19317246 | 0.81 | HTR7 (0.48) | HTR7TLR8TLR7NAMPTHDAC4 | |
| SCHEMBL28506371 | 0.80 | NAMPT (0.51) | TLR8TLR7NAMPTHDAC4ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356893-A | Antidepressants, nervous system disorders | GLAXO GROUP LIMITED (GB) | 1994-10-18 | — | — | US | disclosed |
| EP-0533266-A1 | Benzanilide derivatives as 5-HT1D antagonists | GLAXO GROUP LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |