Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 12/20 | 0.63 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9299722 | 0.91 | TOP2A (0.64) | TOP2ATOP2BKDM4EPOLBGLA | |
| SCHEMBL9300642 | 0.90 | TOP2A (0.60) | TOP2ATOP2BKDM4EPOLBGLA | |
| SCHEMBL9300797 | 0.89 | TOP2A (0.67) | TOP2ATOP2BKDM4EPOLBGLA | |
| SCHEMBL9300912 | 0.89 | TOP2A (0.53) | TOP2ATOP2BKDM4EPOLBGLA | |
| SCHEMBL9300671 | 0.87 | TOP2A (0.66) | TOP2ATOP2BKDM4EPOLBGLA | |
| SCHEMBL9299922 | 0.86 | TOP2A (0.56) | TOP2ATOP2BKDM4EPOLBMAPT | |
| SCHEMBL9299935 | 0.83 | TOP2A (0.68) | TOP2ATOP2BKDM4EPOLBGLA | |
| SCHEMBL9300667 | 0.83 | TOP2A (0.53) | TOP2ATOP2BKDM4EPOLBGLA | |
| SCHEMBL9300814 | 0.83 | TOP2A (0.64) | TOP2ATOP2BKDM4EPOLBGLA | |
| SCHEMBL9300848 | 0.83 | TOP2A (0.64) | TOP2ATOP2BKDM4EPOLBGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354864-A | Antitumor agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-10-11 | — | — | US | claimed |