Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 8/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | AS3MT | Q9HBK9 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12316936 | 0.77 | MAOB (0.57) | ALOX5MAOBP2RY14IMPDH2MAOA | |
| SCHEMBL9301481 | 0.77 | P2RY14 (0.57) | ALOX5P2RY14FFAR1KDM4EMEN1 | |
| SCHEMBL7837193 | 0.75 | MAOB (0.75) | ALOX5MAOBIMPDH2MAOAAS3MT | |
| SCHEMBL6100031 | 0.73 | MAOB (0.71) | ALOX5MAOBIMPDH2MAOAAS3MT | |
| SCHEMBL1723830 | 0.71 | FFAR1 (0.59) | MAOBMAOAFFAR1KDM4EMEN1 | |
| SCHEMBL2735788 | 0.70 | MAOB (0.76) | ALOX5MAOBIMPDH2MAOAFFAR1 | |
| SCHEMBL403151 | 0.69 | MAOB (1.00) | ALOX5MAOBMAOAMAPT | |
| SCHEMBL27704705 | 0.68 | FFAR1 (0.58) | ALOX5MAOBMAOAFFAR1KDM4E | |
| SCHEMBL29941810 | 0.67 | MAOB (0.70) | ALOX5MAOBMAOAMAPT | |
| SCHEMBL538272 | 0.66 | MAOB (0.69) | MAOBMAOAFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5308852-A | Cardiovascular disorders | MERCK FROSST CANADA, INC. (CA) | 1994-05-03 | — | — | US | disclosed |
| EP-0579304-A1 | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1994-01-19 | — | — | EP | disclosed |
| WO-1994000444-A1 | HETEROARYLNAPHTHALENES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-01-06 | — | — | WO | disclosed |