Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300644 | 0.85 | P2RY14 (0.78) | P2RY14ALOX5LMNAHPGDLTB4R | |
| SCHEMBL9022751 | 0.80 | LMNA (0.66) | P2RY14ALOX5LMNAHPGDLTB4R | |
| SCHEMBL9023224 | 0.78 | LTB4R (0.59) | P2RY14ALOX5LMNAHPGDLTB4R | |
| SCHEMBL1779167 | 0.77 | ALOX5 (0.59) | P2RY14ALOX5LMNAHPGDNPC1 | |
| SCHEMBL9022779 | 0.77 | LTB4R (0.56) | P2RY14ALOX5LMNAHPGDLTB4R | |
| SCHEMBL9300748 | 0.77 | ALOX5 (0.50) | P2RY14ALOX5TP53MAPTMEN1 | |
| SCHEMBL9023228 | 0.77 | P2RY14 (0.53) | P2RY14ALOX5LMNAHPGDLTB4R | |
| SCHEMBL9022950 | 0.77 | P2RY14 (0.53) | P2RY14ALOX5LMNAHPGDLTB4R | |
| SCHEMBL9022773 | 0.77 | P2RY14 (0.53) | P2RY14ALOX5LMNAHPGDLTB4R | |
| SCHEMBL27416082 | 0.76 | P2RY14 (0.55) | P2RY14ALOX5LMNAHPGDLTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5308852-A | Cardiovascular disorders | MERCK FROSST CANADA, INC. (CA) | 1994-05-03 | — | — | US | disclosed |
| EP-0579304-A1 | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1994-01-19 | — | — | EP | disclosed |
| WO-1994000444-A1 | HETEROARYLNAPHTHALENES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-01-06 | — | — | WO | disclosed |