Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 5/20 | 0.37 |
| ▸ | NOS3 | P29474 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31672808 | 1.00 | HTR7 (0.42) | HTR7LOXL2MAPTKDM4ECYP3A4 | |
| SCHEMBL6915880 | 0.83 | HTR7 (0.46) | HTR7LOXL2MAPTKDM4ECYP3A4 | |
| SCHEMBL5398528 | 0.83 | LOXL2 (0.43) | HTR7LOXL2MAPTKDM4ECYP3A4 | |
| SCHEMBL19575631 | 0.82 | KMT2A (0.38) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL13555140 | 0.81 | KMT2A (0.36) | LOXL2MAPTKDM4ECYP3A4MEN1 | |
| Hydrochloric Acid SCHEMBL5385071 | 0.81 | MAPT (0.46) | HTR7LOXL2MAPTKDM4ECYP3A4 | |
| SCHEMBL1253514 | 0.80 | HTR7 (0.50) | HTR7LOXL2MAPTKDM4ECYP3A4 | |
| SCHEMBL17450417 | 0.79 | SKP2 (0.53) | HTR7LOXL2MAPTKDM4ECYP3A4 | |
| SCHEMBL17176781 | 0.78 | LOXL2 (0.39) | HTR7LOXL2MAPTKDM4ECYP3A4 | |
| SCHEMBL2518817 | 0.78 | SLC6A4 (0.47) | HTR7LOXL2MAPTKDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356893-A | Antidepressants, nervous system disorders | GLAXO GROUP LIMITED (GB) | 1994-10-18 | — | — | US | disclosed |
| EP-0533266-A1 | Benzanilide derivatives as 5-HT1D antagonists | GLAXO GROUP LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |