Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | MLYCD | O95822 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.42 |
| ▸ | CHRNG | P07510 | 1/20 | 0.42 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19623314 | 0.87 | HPGD (0.77) | HPGDMLYCDPOLBEGFRERBB2 | |
| SCHEMBL9299563 | 0.87 | HPGD (0.76) | HPGDMLYCDMEN1KMT2ACHRNA1 | |
| SCHEMBL14311715 | 0.84 | HPGD (0.52) | HPGDMLYCDEGFRERBB2TP53 | |
| SCHEMBL9300210 | 0.80 | PDK2 (0.47) | HPGDTP53MEN1KMT2AHDAC1 | |
| SCHEMBL3857013 | 0.79 | HPGD (0.53) | HPGDMLYCDPOLBEGFRERBB2 | |
| SCHEMBL22351334 | 0.79 | HPGD (0.59) | HPGDMLYCDEGFRERBB2MEN1 | |
| SCHEMBL9694832 | 0.78 | MLYCD (0.72) | HPGDMLYCDEGFRERBB2TP53 | |
| SCHEMBL7454658 | 0.78 | MLYCD (0.62) | HPGDMLYCDPOLBEGFRERBB2 | |
| SCHEMBL849656 | 0.78 | HPGD (0.49) | HPGDPOLBMEN1KMT2ACHRNA1 | |
| SCHEMBL1638498 | 0.77 | TDP1 (0.56) | HPGDMLYCDEGFRERBB2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356893-A | Antidepressants, nervous system disorders | GLAXO GROUP LIMITED (GB) | 1994-10-18 | — | — | US | disclosed |
| EP-0533266-A1 | Benzanilide derivatives as 5-HT1D antagonists | GLAXO GROUP LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |