Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 5/20 | 0.82 |
| ▸ | HTR1B | P28222 | 3/20 | 0.82 |
| ▸ | HTR2A | P28223 | 3/20 | 0.82 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | WDR5 | P61964 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.46 |
| ▸ | HTR1F | P30939 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9299637 | 0.87 | HTR1D (0.62) | HTR1DHTR1BHTR2ANPC1RAB9A | |
| SCHEMBL9333009 | 0.86 | HTR1D (0.60) | HTR1DHTR1BHTR2ANPC1RAB9A | |
| SCHEMBL7803371 | 0.85 | HTR1D (1.00) | HTR1DHTR1BHTR2ANPC1RAB9A | |
| SCHEMBL8985970 | 0.81 | HTR1D (0.92) | HTR1DHTR1BHTR2ANPC1RAB9A | |
| SCHEMBL9300303 | 0.80 | HTR1D (0.58) | HTR1DHTR1BHTR2ANPC1RAB9A | |
| SCHEMBL9300324 | 0.79 | HTR1D (0.57) | HTR1DHTR1BHTR2ANPC1RAB9A | |
| SCHEMBL9054239 | 0.79 | HTR1D (0.68) | HTR1DHTR1BHTR2ANPC1RAB9A | |
| SCHEMBL9050530 | 0.79 | HTR1D (0.68) | HTR1DHTR1BHTR2ANPC1RAB9A | |
| SCHEMBL9089296 | 0.79 | HTR1D (0.71) | HTR1DHTR1BHTR2ANPC1RAB9A | |
| SCHEMBL24670735 | 0.78 | MAOB (0.62) | HTR1DHTR1BHTR2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356893-A | Antidepressants, nervous system disorders | GLAXO GROUP LIMITED (GB) | 1994-10-18 | — | — | US | disclosed |
| EP-0533266-A1 | Benzanilide derivatives as 5-HT1D antagonists | GLAXO GROUP LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |