Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.43 |
| ▸ | SGK1 | O00141 | 1/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2926113 | 0.78 | EGFR (0.51) | MEN1KMT2AEGFRP2RY14PTGS2 | |
| SCHEMBL9300644 | 0.77 | P2RY14 (0.78) | P2RY14ALOX5 | |
| SCHEMBL29138977 | 0.76 | MEN1 (0.50) | MEN1KMT2AEGFRPTGS2LCK | |
| SCHEMBL5776604 | 0.75 | PTPN11 (0.54) | LCKCYP4F2CYP4A11CYP19A1CYP11B1 | |
| SCHEMBL9303741 | 0.75 | MEN1 (0.52) | MEN1KMT2AEGFRPTGS2LCK | |
| SCHEMBL7824090 | 0.75 | EGFR (0.52) | MEN1KMT2AEGFRPTGS2SGK1 | |
| SCHEMBL9302368 | 0.74 | KDM4E (0.54) | MEN1KMT2AP2RY14ALOX5 | |
| SCHEMBL3149487 | 0.74 | CYP4A11 (0.50) | LCKCYP4F2CYP4A11CYP19A1CYP11B1 | |
| SCHEMBL10458005 | 0.74 | PTGS2 (0.76) | MEN1KMT2AEGFRPTGS2KIF11 | |
| SCHEMBL16502556 | 0.72 | EGFR (0.54) | MEN1KMT2AEGFRPTGS2GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1087907-A | Heteroaryl naphthalene as white (cell) triolefin biosynthesis inhibitor | MERCK FROSST CANADA INC (CA) | 1994-06-15 | — | — | CN | disclosed |
| US-5308852-A | Cardiovascular disorders | MERCK FROSST CANADA, INC. (CA) | 1994-05-03 | — | — | US | disclosed |
| EP-0579304-A1 | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1994-01-19 | — | — | EP | disclosed |
| WO-1994000444-A1 | HETEROARYLNAPHTHALENES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-01-06 | — | — | WO | disclosed |