Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 1/20 | 0.78 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300510 | 0.88 | P2RY14 (1.00) | P2RY14ALOX5HPGDMAOBLTB4R | |
| SCHEMBL9022751 | 0.86 | LMNA (0.66) | P2RY14ALOX5LMNAHPGDMAOB | |
| SCHEMBL9301481 | 0.85 | P2RY14 (0.57) | P2RY14ALOX5LMNAHPGDLTB4R | |
| SCHEMBL9022779 | 0.84 | LTB4R (0.56) | P2RY14ALOX5LMNAHPGDMAOB | |
| SCHEMBL9301439 | 0.84 | P2RY14 (0.78) | P2RY14ALOX5MAOBLTB4RLTB4R2 | |
| SCHEMBL9301058 | 0.83 | P2RY14 (0.73) | P2RY14ALOX5MAOBLTB4RLTB4R2 | |
| SCHEMBL9023224 | 0.83 | LTB4R (0.59) | P2RY14ALOX5LMNAHPGDMAOB | |
| SCHEMBL1779167 | 0.82 | ALOX5 (0.59) | P2RY14ALOX5LMNAHPGDMAOB | |
| SCHEMBL9022950 | 0.82 | P2RY14 (0.53) | P2RY14ALOX5LMNAHPGDMAOB | |
| SCHEMBL9023228 | 0.82 | P2RY14 (0.53) | P2RY14ALOX5LMNAHPGDMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1087907-A | Heteroaryl naphthalene as white (cell) triolefin biosynthesis inhibitor | MERCK FROSST CANADA INC (CA) | 1994-06-15 | — | — | CN | disclosed |
| US-5308852-A | Cardiovascular disorders | MERCK FROSST CANADA, INC. (CA) | 1994-05-03 | — | — | US | disclosed |
| EP-0579304-A1 | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1994-01-19 | — | — | EP | disclosed |
| WO-1994000444-A1 | HETEROARYLNAPHTHALENES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-01-06 | — | — | WO | disclosed |