Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 3/20 | 0.51 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29126150 | 0.83 | KAT2B (0.63) | KAT2BSIRT5MAPTHCAR3NPC1 | |
| SCHEMBL30697331 | 0.83 | KAT2B (0.63) | KAT2BSIRT5MAPTHCAR3NPC1 | |
| SCHEMBL14616761 | 0.74 | LMNA (0.70) | KAT2BMAPTHCAR3SMN1; SMN2RAB9A | |
| SCHEMBL6969883 | 0.74 | MAPT (0.59) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3636228 | 0.72 | KAT2B (0.69) | KAT2BMAPTHCAR3NPC1RAB9A | |
| SCHEMBL8313477 | 0.72 | KAT2B (0.69) | KAT2BMAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL15060715 | 0.72 | KAT2B (0.61) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9301798 | 0.71 | KAT2B (0.60) | KAT2BMAPTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL12672113 | 0.71 | KAT2B (0.56) | KAT2BMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL981242 | 0.69 | KAT2B (0.64) | KAT2BMAPTHCAR3ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994012163-A1 | 2-NITROARYL AND 2-CYANOARYL COMPOUNDS AS REGULATORS OF NITRIC OXIDE SYNTHASE | ABBOTT LABORATORIES (US) | 1994-06-09 | — | — | WO | claimed |
| US-5362747-A | Promoters, inhibitors | ABBOTT LABORATORIES (US) | 1994-11-08 | — | — | US | disclosed |
| WO-1994012163-A1 | 2-NITROARYL AND 2-CYANOARYL COMPOUNDS AS REGULATORS OF NITRIC OXIDE SYNTHASE | ABBOTT LABORATORIES (US) | 1994-06-09 | — | — | WO | disclosed |