Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 4/20 | 0.45 |
| ▸ | CTSS | P25774 | 3/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27543265 | 1.00 | HTT (0.47) | HTTSIRT2CTSLCTSSKEAP1 | |
| SCHEMBL333826 | 1.00 | HTT (0.47) | HTTSIRT2CTSLCTSSKEAP1 | |
| SCHEMBL7378143 | 0.90 | CTSL (0.56) | CTSLCTSSCTSBCTSK | |
| SCHEMBL27559585 | 0.90 | LGMN (0.45) | CTSLCTSSCTSBCTSK | |
| SCHEMBL7378138 | 0.90 | CTSL (0.56) | CTSLCTSSCTSBCTSK | |
| SCHEMBL11511471 | 0.90 | HTT (0.46) | HTTSIRT2CTSLCTSSKEAP1 | |
| SCHEMBL27562471 | 0.89 | CTSL (0.48) | HTTSIRT2CTSLCTSSCTSB | |
| SCHEMBL4539198 | 0.86 | FOLH1 (0.58) | HTTKEAP1NFE2L2FOLH1LMNA | |
| SCHEMBL4560825 | 0.86 | FOLH1 (0.58) | HTTKEAP1NFE2L2FOLH1LMNA | |
| SCHEMBL10558519 | 0.86 | FOLH1 (0.58) | HTTKEAP1NFE2L2FOLH1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4505852-A | 7-Amino-4-trifluoromethylquinolone derived substrates and method for determining enzymes and inhibitors | ENZYME SYSTEMS PRODUCTS (US) | 1985-03-19 | — | — | US | claimed |
| US-5342970-A | Hydrosoluble coumarin derivatives, their preparation and their use as an enzyme substrate or for the preparation of such substrates | LABORATOIRES EUROBIO (FR) | 1994-08-30 | — | — | US | disclosed |
| US-4505852-A | 7-Amino-4-trifluoromethylquinolone derived substrates and method for determining enzymes and inhibitors | ENZYME SYSTEMS PRODUCTS (US) | 1985-03-19 | — | — | US | disclosed |