Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.53 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301723 | 0.79 | ALOX5 (0.44) | ALOX5 | |
| SCHEMBL3648539 | 0.71 | MAOB (1.00) | MAOBIMPDH2ALOX5MAOANSD2 | |
| SCHEMBL7837193 | 0.69 | MAOB (0.75) | MAOBIMPDH2ALOX5MAOANPC1 | |
| SCHEMBL3865512 | 0.69 | MAOB (0.77) | MAOBIMPDH2ALOX5MAOANSD2 | |
| SCHEMBL4260225 | 0.69 | MAOB (0.77) | MAOBIMPDH2ALOX5MAOANSD2 | |
| SCHEMBL13523861 | 0.69 | MAOB (0.58) | MAOBIMPDH2ALOX5MAOANSD2 | |
| SCHEMBL13523862 | 0.68 | MAOB (0.57) | MAOBIMPDH2ALOX5MAOA | |
| SCHEMBL23887978 | 0.68 | MAOB (0.74) | MAOBIMPDH2ALOX5MAOARAB9A | |
| SCHEMBL21124838 | 0.68 | MAOB (0.74) | MAOBIMPDH2ALOX5MAOARAB9A | |
| SCHEMBL14677247 | 0.68 | MAOB (0.74) | MAOBIMPDH2ALOX5MAOANSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5308852-A | Cardiovascular disorders | MERCK FROSST CANADA, INC. (CA) | 1994-05-03 | — | — | US | disclosed |
| EP-0579304-A1 | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1994-01-19 | — | — | EP | disclosed |
| WO-1994000444-A1 | HETEROARYLNAPHTHALENES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-01-06 | — | — | WO | disclosed |