Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 20/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9302861 | 0.84 | ALOX5 (0.62) | ALOX5 | |
| SCHEMBL9265197 | 0.80 | ALOX5 (0.42) | ALOX5 | |
| SCHEMBL9301413 | 0.79 | MAOB (0.53) | ALOX5 | |
| SCHEMBL9301706 | 0.78 | ALOX5 (0.46) | ALOX5 | |
| SCHEMBL9159702 | 0.78 | GRM4 (0.40) | ALOX5 | |
| SCHEMBL9301699 | 0.77 | ALOX5 (0.44) | ALOX5 | |
| SCHEMBL9301510 | 0.76 | ALOX5 (0.51) | ALOX5 | |
| SCHEMBL9261102 | 0.76 | MAOB (0.49) | ALOX5 | |
| SCHEMBL9301503 | 0.76 | ALOX5 (0.60) | ALOX5 | |
| SCHEMBL9301768 | 0.76 | ALOX5 (0.45) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5308852-A | Cardiovascular disorders | MERCK FROSST CANADA, INC. (CA) | 1994-05-03 | — | — | US | disclosed |
| EP-0579304-A1 | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1994-01-19 | — | — | EP | disclosed |
| WO-1994000444-A1 | HETEROARYLNAPHTHALENES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-01-06 | — | — | WO | disclosed |