Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 9/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA4 | P22748 | 1/20 | 0.51 |
| ▸ | CA5A | P35218 | 1/20 | 0.51 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
| ▸ | GAB1 | Q13480 | 1/20 | 0.47 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11891722 | 0.83 | AKT1 (0.57) | AKT1MEN1TSHRKMT2ACA1 | |
| SCHEMBL282714 | 0.82 | AKT1 (1.00) | AKT1MEN1TSHRKMT2ACA1 | |
| SCHEMBL299526 | 0.82 | AKT1 (0.71) | AKT1MEN1TSHRKMT2APOLB | |
| SCHEMBL3154274 | 0.80 | CA1 (0.61) | AKT1MEN1TSHRKMT2ACA1 | |
| SCHEMBL1094038 | 0.80 | AKT1 (0.53) | AKT1MEN1TSHRKMT2ASCN9A | |
| SCHEMBL9301358 | 0.79 | ALDH1A1 (0.57) | AKT1MEN1TSHRKMT2ACA1 | |
| SCHEMBL24477126 | 0.78 | AKT1 (0.51) | AKT1MEN1TSHRKMT2APKM | |
| SCHEMBL9301181 | 0.77 | ALDH1A1 (0.69) | MEN1KMT2APOLBPKMALDH1A1 | |
| SCHEMBL3168504 | 0.77 | MEN1 (0.56) | AKT1MEN1TSHRKMT2ACA1 | |
| SCHEMBL11891709 | 0.75 | AKT1 (0.62) | AKT1MEN1TSHRKMT2ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360802-A | Antagonists of cholecystokinin and gastrin | MERCK SHARPE & DOHME LTD. | 1994-11-01 | — | — | US | disclosed |
| EP-0514133-A1 | Benzodiazepine derivatives, compositions containing them and their use in therapy | MERCK SHARP & DOHME LTD. (GB) | 1992-11-19 | — | — | EP | disclosed |