Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | RAD52 | P43351 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | LY6K | Q17RY6 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300026 | 0.85 | TOP2B (0.46) | TOP2ATOP2BKMT2APOLBKDM4E | |
| SCHEMBL9300424 | 0.83 | TOP2A (0.60) | TOP2ATOP2BKMT2APOLBKDM4E | |
| SCHEMBL9300047 | 0.77 | KMT2A (0.53) | TOP2ATOP2BKMT2APOLBKDM4E | |
| SCHEMBL9300158 | 0.75 | TOP2A (0.50) | TOP2ATOP2BKMT2APOLBKDM4E | |
| SCHEMBL9300142 | 0.74 | TOP2A (0.56) | TOP2ATOP2BKMT2APOLBKDM4E | |
| SCHEMBL9301426 | 0.73 | TOP2A (0.55) | TOP2ATOP2BKMT2APOLBKDM4E | |
| SCHEMBL9300653 | 0.72 | POLB (0.47) | TOP2ATOP2BKMT2APOLBKDM4E | |
| SCHEMBL9299772 | 0.71 | TOP2A (0.62) | TOP2ATOP2BKMT2APOLBKDM4E | |
| SCHEMBL9301920 | 0.70 | TOP2A (0.45) | TOP2ATOP2BKMT2APOLBKDM4E | |
| SCHEMBL9300901 | 0.69 | KDM4E (0.48) | TOP2ATOP2BKMT2APOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354864-A | Antitumor agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-10-11 | — | — | US | disclosed |
| US-5332853-A | Alkylating tetrachlorosilane or an alkylchlorosilane with an alkyllithium using ether, metal alkoxide, amine, or metal amide as catalyst | FMC CORPORATION (US) | 1994-07-26 | — | — | US | disclosed |
| EP-0525880-A1 | Catalytic alkylation process | FMC CORPORATION (US) | 1993-02-03 | — | — | EP | disclosed |
| US-4440965-A | AVERAGE MOLECULAR WEIGHT OF 150 TO 3000 | PHILLIPS PETROLEUM COMPANY (US) | 1984-04-03 | — | — | US | disclosed |