Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.56 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300158 | 0.88 | TOP2A (0.50) | TOP2ATOP2BKDM4EMAPTKMT2A | |
| SCHEMBL9300065 | 0.81 | TOP2A (0.83) | TOP2ATOP2BKDM4EMAPTKMT2A | |
| SCHEMBL9300047 | 0.81 | KMT2A (0.53) | TOP2ATOP2BKDM4EMAPTKMT2A | |
| SCHEMBL9300026 | 0.77 | TOP2B (0.46) | TOP2ATOP2BKDM4EMAPTKMT2A | |
| SCHEMBL9299786 | 0.75 | TOP2A (0.78) | TOP2ATOP2BKDM4EMAPTKMT2A | |
| SCHEMBL9300434 | 0.75 | TOP2A (0.78) | TOP2ATOP2BKDM4EMAPTKMT2A | |
| SCHEMBL9301849 | 0.74 | TOP2A (0.43) | TOP2ATOP2BKDM4EMAPTKMT2A | |
| SCHEMBL9302060 | 0.72 | TOP2A (0.76) | TOP2ATOP2BKDM4EMAPTKMT2A | |
| SCHEMBL9301920 | 0.71 | TOP2A (0.45) | TOP2ATOP2BKDM4EMAPTKMT2A | |
| SCHEMBL9300052 | 0.70 | TOP2A (0.73) | TOP2ATOP2BKDM4EMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354864-A | Antitumor agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-10-11 | — | — | US | claimed |
| US-5354864-A | Antitumor agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-10-11 | — | — | US | disclosed |