Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300867 | 0.86 | ALOX5 (0.62) | ALOX5MRGPRX4P2RY14 | |
| SCHEMBL9302072 | 0.85 | ALOX5 (0.47) | ALOX5GPR84MRGPRX4PRKDCP2RY14 | |
| SCHEMBL9301510 | 0.84 | ALOX5 (0.51) | ALOX5MRGPRX4P2RY14 | |
| SCHEMBL9301373 | 0.83 | ALOX5 (0.46) | ALOX5GPR84MRGPRX4PRKDCP2RY14 | |
| SCHEMBL9301768 | 0.82 | ALOX5 (0.45) | ALOX5GPR84MRGPRX4PRKDC | |
| SCHEMBL9382166 | 0.79 | ALOX5 (0.61) | ALOX5P2RY14 | |
| SCHEMBL9302530 | 0.78 | P2RY14 (0.63) | ALOX5MRGPRX4P2RY14 | |
| SCHEMBL9162779 | 0.77 | ALOX5 (0.44) | ALOX5P2RY14 | |
| SCHEMBL9301164 | 0.75 | P2RY14 (0.49) | ALOX5P2RY14 | |
| SCHEMBL9300305 | 0.74 | ALOX5 (0.59) | ALOX5P2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5308852-A | Cardiovascular disorders | MERCK FROSST CANADA, INC. (CA) | 1994-05-03 | — | — | US | disclosed |
| EP-0579304-A1 | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1994-01-19 | — | — | EP | disclosed |
| WO-1994000444-A1 | HETEROARYLNAPHTHALENES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-01-06 | — | — | WO | disclosed |