SCHEMBL9302120

SCHEMBL9302120

Cl[SiH2]C(c1ccccc1)c1cccc2ccccc12

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.47
CYP1A2 P05177 2/20 0.47
CYP2C9 P11712 2/20 0.47
CYP2C19 P33261 2/20 0.47
SLC6A4 P31645 1/20 0.45
CYP2A6 P11509 2/20 0.38
ACP3 P15309 3/20 0.37
HPGD P15428 1/20 0.36
HTT P42858 1/20 0.36
ADRA2A P08913 1/20 0.35
ADRA2B P18089 1/20 0.35
ADRA2C P18825 1/20 0.35
ADRA1D P25100 1/20 0.35
ADRA1A P35348 1/20 0.35
ADRA1B P35368 1/20 0.35
TSHR P16473 1/20 0.34
HSD17B10 Q99714 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17966501 0.88 ALDH1A1 (0.54) ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4
SCHEMBL11524431 0.81 ALDH1A1 (0.47) ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4
SCHEMBL245489 0.75 TSHR (0.48) SLC6A4TSHRTDP1LMNA
SCHEMBL7912353 0.75 ALDH1A1 (0.52) ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4
SCHEMBL30575787 0.75 ALDH1A1 (0.52) ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4
SCHEMBL40516 0.74 ALDH1A1 (0.56) ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4
SCHEMBL5012390 0.74 ALDH1A1 (0.56) ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4
SCHEMBL1315055 0.73 ACP3 (0.44) CYP2C9CYP2C19SLC6A4ACP3ADRA2A
SCHEMBL1314988 0.73 ACP3 (0.38) CYP1A2CYP2C9CYP2C19SLC6A4ACP3
SCHEMBL5010807 0.72 ALDH1A1 (0.54) ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5354772-A Anticholesterol agents SANDOZ PHARM. CORP. (US) 1994-10-11 US disclosed
US-5001255-A Idene analogs of mevalonolactone and derivatives thereof SANDOZ PHARM. CORP. (US) 1991-03-19 US disclosed
US-4973704-A ANTICHOLESTEROL AGENTS SANDOZ PHARM. CORP. (US) 1990-11-27 US disclosed
EP-0235164-B1 IMIDAZOLE ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF SANDOZ AG (CH) 1990-07-25 EP disclosed
US-4876280-A ANTICHOLESTEROL AGENTS; ATHEROSCLEROSIS; ANTILIPEMICS SANDOZ PHARM. CORP. (US) 1989-10-24 US disclosed
EP-0327500-A2 5-Substituted 1H-pyrazolo[3,4-b]pyridine derivatives, their preparation and pharmaceutical compositions containing them SANDOZ AG (CH) 1989-08-09 EP disclosed
US-4851427-A INHJIBITORS OF CHOLESTEROL BIOSYNTHESIS SANDOZ PHARM. CORP. (US) 1989-07-25 US disclosed
US-4822799-A Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals SANDOZ PHARM. CORP. (US) 1989-04-18 US disclosed
US-4808607-A ATHEROSCLEROSIS, HYPERLIPOPROTEINEMIA SANDOZ PHARM. CORP. (US) 1989-02-28 US disclosed
US-4804679-A INHIBIT CHOLESTEROL BIOSYNTHESIS SANDOZ PHARM. CORP. (US) 1989-02-14 US disclosed
US-4755606-A Imidazolyl-3,5-di-(diphenyl-butylsilyloxy) carboxylic acid ester intermediates SANDOZ PHARM. CORP. (US) 1988-07-05 US disclosed
US-4739073-A ANTICHOLESTEROL AGENTS SANDOZ PHARMACEUTICALS CORP. (US) 1988-04-19 US disclosed
EP-0114027-B1 ANALOGS OF MEVALOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS PHARMACEUTICALS SANDOZ AG (CH) 1988-01-07 EP disclosed
EP-0235164-A1 IMIDAZOLE ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF. SANDOZ AG (CH) 1987-09-09 EP disclosed
US-4686237-A LOWERING BLOOD CHOLESTEROL LEVEL SANDOZ PHARMACEUTICALS CORP. (US) 1987-08-11 US disclosed
US-4668794-A CHOLESTEROL BIOSYNTHESIS INHIBITORS SANDOZ PHARM. CORP. (US) 1987-05-26 US disclosed
WO-1986007054-A1 IMIDAZOLE ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF SANDOZ AG (CH) 1986-12-04 WO disclosed
US-4613610-A TREATING ATHEROSCLEROSIS AND HYPERLIPEMIA SANDOZ PHARMACEUTICALS CORP. (US) 1986-09-23 US disclosed